{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:55:57Z","timestamp":1779292557000,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The present study aimed to examine the association between the conditioning intensity and height growth in pediatric patients who underwent allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the clinical records of 89 children with malignant diseases who underwent initial allo\u2010HSCT between 2003 and 2021. Height measurements were standardized using standard height charts prepared by the Japanese Society for Pediatric Endocrinology to calculate standard deviation score (SDS). We defined short stature as a height SDS less than \u22122.0 in that reference. Myeloablative conditioning (MAC) comprised total\u2010body irradiation at more than 8\u2009Gy and busulfan administration at more than 8\u2009mg\/kg (more than 280\u2009mg\/m<jats:sup>2<\/jats:sup>). Other conditioning regimens were defined as reduced intensity conditioning (RIC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 58 patients underwent allo\u2010HSCT with MAC, and 31 patients received allo\u2010HSCT with RIC. There were significant differences in the height SDS at 2 and 3\u2009years after allo\u2010HSCT between MAC and RIC group (\u22121.33\u2009\u00b1\u20091.20 vs. \u22120.76\u2009\u00b1\u20091.12, <jats:italic>p<\/jats:italic>\u2009=\u20090.047, \u22121.55\u2009\u00b1\u20091.28 vs. \u22120.75\u2009\u00b1\u20091.11, <jats:italic>p<\/jats:italic>\u2009=\u20090.022, respectively). Multivariate logistic regression analysis with the adjustments for potential confounding factors of patients less than 10\u2009years of age at allo\u2010HSCT and chronic graft\u2010versus host disease demonstrated that MAC regimen was associated with a markedly increased risk of a short stature at 3\u2009years after allo\u2010HSCT (adjusted odds ratio, 5.61; 95% confidence interval, 1.07\u201329.4; <jats:italic>p<\/jats:italic>\u2009=\u20090.041).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The intensity of conditioning regimen may be associated with short statures after allo\u2010HSCT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6336","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T05:39:22Z","timestamp":1689140362000},"page":"17018-17027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between conditioning intensity and height growth after allogeneic hematopoietic stem cell transplantation in children"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7461-9138","authenticated-orcid":false,"given":"Suguru","family":"Uemura","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Kobe Children's Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiichiro","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Kobe Children's Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Kobe Children's Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Fujikawa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Kobe Children's Hospital  Kobe 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