{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:18:50Z","timestamp":1789723130036,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In the study, we aimed to evaluate the ability of micro\u2010histology combined with cytology to improve the quality of slides and diagnose endometrial lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Endometrial specimens were collected from Li Brushes. Every specimen was prepared for micro\u2010histological and cytological slides, using cell block (CB) and liquid\u2010based cytology (LBC) technologies. Semi\u2010quantitative scoring system was used to evaluate the qualities of slides. CB slides were assessed by 5\u2010category scoring system. Diagnostic accuracy was calculated in LBC, CB, and LBC\u2009+\u2009CB groups based on the histological gold standard. Endometrial atypical hyperplasia, and endometrial cancer were considered positive, whereas others were considered negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 167 patients were enrolled. CB slides were inferior to LBC slides only in cellularity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but superior in the other six parameters (all<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The satisfaction rate of micro\u2010histology accounted for 92.3%. The accuracy index in the CB group was higher than in the LBC group in terms of sensitivity (85.5% vs. 82.7%) and specificity (98.9% vs. 95.7%). The sensitivity and specificity in the LBC\u2009+\u2009CB group were increased to 94.2% and 99.0%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The quality of micro\u2010histological slides was higher than that of cytological slides. By combining micro\u2010histology with cytology, higher accuracy was achieved for endometrial lesions diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6338","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T09:28:08Z","timestamp":1689586088000},"page":"17028-17036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Micro\u2010histology combined with cytology improves the diagnostic accuracy of endometrial lesions"],"prefix":"10.1002","volume":"12","author":[{"given":"Yiran","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanbo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Xi'an Jiaotong 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