{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:46:18Z","timestamp":1785800778284,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special Fund","doi-asserted-by":"publisher","award":["2018\u2010 2\u20102054"],"award-info":[{"award-number":["2018\u2010 2\u20102054"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We performed a paired analysis to compare the therapeutic effect between the induction chemotherapy\u2010based organ\u2010preservation approach and immediate total laryngectomy in hypopharyngeal squamous cell carcinoma patients requiring total laryngectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>351 patients who were treated with organ\u2010preservation approach were compared with 110 patients who were treated with total laryngectomy. The main measures and outcomes were progression\u2010free survival (PFS), overall survival (OS), and larynx function preservation survival (LFPS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistical difference was observed for 3\u2010, 5\u2010, and 10\u2010year PFS and OS in two groups. In the organ\u2010preservation group, the 3\u2010, 5\u2010, and 10\u2010year LFPS was 30.7%, 23.3%, and 16.6%, respectively. The LFPS of Stage III\u2009&gt;\u2009Stage IV, N0\u2009&gt;\u2009N1\u2009&gt;\u2009N2\u2009&gt;\u2009N3, T2\u2009&gt;\u2009T3\u2009&gt;\u2009T4, CR\u2009&gt;\u2009PR\u2009&gt;\u2009SD\u2009&gt;\u2009PD patients (all <jats:italic>p<\/jats:italic> values &lt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Survival outcomes did not significantly differ between the two groups. The organ\u2010preservation approach allowed more than 70% of the survivors to retain their larynx function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6354","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T13:19:21Z","timestamp":1689772761000},"page":"17078-17086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Induction chemotherapy\u2010based organ\u2010preservation protocol improve the function preservation compared with immediate total laryngectomy for locally advanced hypopharyngeal cancer\u2014Results of a matched\u2010pair analysis"],"prefix":"10.1002","volume":"12","author":[{"given":"Yifan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital Capital Medical University  Beijing China"},{"name":"Key Laboratory of Otorhinolaryngology, Head and Neck Surgery Beijing Institute of Otorhinolaryngology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital Capital Medical University  Beijing China"},{"name":"Key Laboratory of Otorhinolaryngology, Head and Neck Surgery Beijing Institute of Otorhinolaryngology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1259-5200","authenticated-orcid":false,"given":"Qi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital Capital Medical University  Beijing China"},{"name":"Key Laboratory of Otorhinolaryngology, Head and Neck Surgery Beijing Institute of Otorhinolaryngology  Beijing 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University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Tong Ren Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Seventh Medical Center General Hospital of the Chinese People's Liberation Army  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital Capital Medical University  Beijing China"},{"name":"Key Laboratory of Otorhinolaryngology, Head and Neck Surgery Beijing Institute of Otorhinolaryngology  Beijing 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