{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:38:20Z","timestamp":1747147100739,"version":"3.40.5"},"reference-count":45,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) and the coronavirus 19 (COVID\u201019) pandemic have had a lasting impact on the care of cancer patients. The impact on patients with gastrointestinal (GI) malignancies remains incompletely understood. We aimed to assess the impact of COVID\u201019 on mortality, length of stay (LOS), and cost of care among patients with GI malignancies, and identify differences in outcomes based on primary tumor site.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed discharge encounters collected from the National Inpatient Sample (NIS) between March 2020 and December 2020 using propensity score matching (PSM) and COVID\u201019 as the treatment effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 87,684 patient discharges with GI malignancies, 1892 were positive for COVID\u201019 (C+) and eligible for matching in the PSM model. Following PSM analysis, C+ with GI tumors demonstrated increased incidence of mortality compared to their COVID\u201019\u2010negative (C\u2010) counterparts (21.3% vs. 11.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). C+ patients with colorectal cancer (CRC) had significantly higher mortality compared to those who were C\u2010 (40% vs. 24%; <jats:italic>p<\/jats:italic>\u2009=\u20090.035). In addition, C+ patients with GI tumors had a longer mean LOS (9.4\u2009days vs. 6.9\u2009days; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and increased cost of care ($26,048.29 vs. $21,625.2; <jats:italic>p<\/jats:italic>\u2009=\u20090.001) compared to C\u2010 patients. C+ patients also had higher odds of mortality secondary to myocardial infarction relative to C\u2010 patients (OR\u2009=\u20093.54, <jats:italic>p<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>C+ patients with GI tumors face approximately double the odds of mortality, increased LOS, and increased cost of care compared to their C\u2010 counterparts. Outcome disparities were most pronounced among patients with CRC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6355","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T07:05:35Z","timestamp":1690787135000},"page":"17365-17376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of <scp>COVID<\/scp>\u201019 on mortality, length of stay, and cost of care among patients with gastrointestinal malignancies: A propensity score\u2010matched analysis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5966-3966","authenticated-orcid":false,"given":"Mark B.","family":"Ulanja","sequence":"first","affiliation":[{"name":"CHRISTUS Ochsner St. Patrick Hospital  Lake Charles Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-1826","authenticated-orcid":false,"given":"Bryce D.","family":"Beutler","sequence":"additional","affiliation":[{"name":"Department of Radiology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwabena Oppong","family":"Asafo\u2010Agyei","sequence":"additional","affiliation":[{"name":"CHRISTUS Highland Medical Center  Shreveport Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel B.","family":"Governor","sequence":"additional","affiliation":[{"name":"School of Medicine Washington University in St Louis  St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Edusa","sequence":"additional","affiliation":[{"name":"Samalla Clinic Ltd.  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