{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T16:30:20Z","timestamp":1750177820117,"version":"3.40.5"},"reference-count":46,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The COVID\u201019 pandemic had global catastrophic effects on the management of non\u2010communicable diseases including paediatric cancers. Restrictions during the start of 2020 complicated timely referrals of patients to specialized centres. We aimed to evaluate the pandemic\u2019s impact on the number of new diagnoses, disease characteristics and management delay for paediatric renal tumour patients included in the SIOP\u2010RTSG\u2010UMBRELLA study, as compared with data from a historical SIOP\u2010RTSG trial (2005\u20132009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The number of intensive care admissions, population mobility rates and national lockdown periods\/restrictions were used as proxies of the pandemic\u2019s severity and impact on societies. Clinical and tumour data were extracted from the SIOP\u2010RTSG\u2010UMBRELLA study and from historical SIOP\u2010RTSG trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the first lockdown in Europe, the number of newly diagnosed patients decreased following restrictions and population immobilisation. Additionally, there was a higher proportion of advanced disease (37% vs. 17% before and after COVID\u20109, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and larger median tumour volume (559 cm<jats:sup>3<\/jats:sup> vs. 328 and 434 cm<jats:sup>3<\/jats:sup> before and after, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Also in Brazil, the proportion of advanced disease was higher during the national decrease in mobilisation and start of restrictions (50% and 24% vs. 11% and 18% before and after, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Tumour volume in Brazil was also higher during the first months of COVID\u201019 (599 cm<jats:sup>3<\/jats:sup> vs. 459 and 514 cm<jats:sup>3<\/jats:sup>), although not significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.17). We did not observe any delays in referral time nor in time to start treatment, even though COVID\u201019 restrictions may have caused children to reach care later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The COVID\u201019 pandemic briefly changed the tumour characteristics of children presenting with renal tumours. The longer\u2010term impact on clinical outcomes will be kept under review.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6358","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T05:30:30Z","timestamp":1690435830000},"page":"17098-17111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of the <scp>COVID<\/scp>\u201019 pandemic on paediatric renal tumour presentation and management, a <scp>SIOP<\/scp> renal tumour study group study"],"prefix":"10.1002","volume":"12","author":[{"given":"Prakriti","family":"Roy","sequence":"first","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5484-9112","authenticated-orcid":false,"given":"Sophie E.","family":"van Peer","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"Dandis","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catriona","family":"Duncan","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim Caetano","family":"de Aguirre\u2010Neto","sequence":"additional","affiliation":[{"name":"Paediatric Haemato\u2010oncology Hospital Santa Casa de Belo Horizonte  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnauld","family":"Verschuur","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology &amp; Haematology La Timone Children's Hospital  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5794-1042","authenticated-orcid":false,"given":"Beatriz","family":"de Camargo","sequence":"additional","affiliation":[{"name":"Grupo Brasileiro de Tumores Renais (Brazilian Renal Tumor Group)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrike E.","family":"Karim\u2010Kos","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Department of Research Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luna","family":"Boschetti","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, Pediatric Oncology Unit Fondazione IRCCS Istituto Nazionale dei Tumori di Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Spreafico","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, Pediatric Oncology Unit Fondazione IRCCS Istituto Nazionale dei Tumori di Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gema L.","family":"Ramirez\u2010Villar","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology Hospital Universitario Virgen del Roc\u00edo  Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2248-323X","authenticated-orcid":false,"given":"Norbert","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology &amp; 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