{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:41:16Z","timestamp":1791819676605,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Body composition alterations are frequent in patients with cancer or chronic liver disease, but their prognostic value remains unclear in many cancer entities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated the impact of disease aetiology and body composition after surgery for intrahepatic cholangiocarcinoma (iCCA), a rare and understudied cancer entity in European and North American cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Computer tomography\u2010based assessment of body composition at the level of the third lumbar vertebra was performed in 173 patients undergoing curative\u2010intent liver resection for iCCA at the Department of Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin. Muscle mass and \u2010composition as well as subcutaneous and visceral adipose tissue quantity were determined semi\u2010automatically. (Secondary) sarcopenia, sarcopenic obesity, myosteatosis, visceral and subcutaneous obesity were correlated to clinicopathological data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sarcopenia was associated with post\u2010operative morbidity (intraoperative transfusions [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027], Clavien\u2013Dindo \u2265 IIIb complications [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030], post\u2010operative comprehensive complication index, CCI [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001]). Inferior overall survival was noted in patients with myosteatosis (33 vs. 23\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020).\n                    <\/jats:p>\n                    <jats:p>\n                      Fifty\u2010eight patients (34%) had metabolic (dysfunction)\u2010associated fatty liver disease (MAFLD) and had a significantly higher incidence of sarcopenic (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), visceral (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and subcutaneous obesity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Patients with MAFLD had longer time\u2010to\u2010recurrence\u00a0(median: 38 vs. 12\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025, log\u2010rank test). Multivariable cox regression analysis confirmed only clinical, and not body, composition parameters (age\u2009&gt;\u200965, fresh frozen plasma transfusions) as independently prognostic for overall survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study evidenced a high prevalence of MAFLD in iCCA, suggesting its potential contribution to disease aetiology. Alterations of muscle mass and adipose tissue were more frequent in patients with MAFLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6374","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T01:37:00Z","timestamp":1690421820000},"page":"17569-17580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Body composition is associated with disease aetiology and prognosis in patients undergoing resection of intrahepatic cholangiocarcinoma"],"prefix":"10.1002","volume":"12","author":[{"given":"Isabella","family":"Lurje","sequence":"first","affiliation":[{"name":"Department of Hepatology and Gastroenterology, Campus Charit\u00e9 Mitte | Campus Virchow\u2010Klinikum Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin 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