{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T19:20:26Z","timestamp":1788636026308,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the feasibility of incorporating bevacizumab consolidation into hypo\u2010fractionated concurrent chemoradiotherapy (hypo\u2010CCRT) for patients with unresectable locally advanced non\u2010squamous non\u2010small\u2010cell lung cancer (LA\u2010NS\u2010NSCLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Eligible patients were treated with hypo\u2010RT (40Gy in 10 fractions) followed by hypo\u2010boost (24\u201028Gy in 6\u20137 fractions), along with concurrent weekly chemotherapy. Patients who completed the hypo\u2010CCRT without experiencing \u2265G2 toxicities received consolidation bevacizumab every 3\u2009weeks for up to 1\u2009year, until disease progression or unacceptable treatment\u2010related toxicities.<\/jats:p>\n                    <jats:p>The primary endpoint was the risk of G4 or higher hemorrhage. Secondary endpoints included progression\u2010free survival (PFS), overall survival (OS), locoregional failure\u2010free survival (LRFS), distant metastasis\u2010free survival (DMFS), and objective response rate (ORR). All time\u2010to\u2010event endpoints (OS, PFS, LRFS, and DMFS) were measured from the start of radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between December 2017 and July 2020, a total of 27 patients were included in the analysis, with a median follow\u2010up duration of 28.0\u2009months. One patient (3.7%) developed G5 hemorrhage during bevacizumab consolidation. Additionally, seven patients (25.9%) had G3 cough and three patients (11.1%) experienced G3 pneumonitis. The ORR for the entire cohort was 92.6%. The median OS was 37.0\u2009months (95% confidence interval, 8.9\u201365.1\u2009months), the median PFS was 16.0\u2009months (95% confidence interval, 14.0\u201318.0\u2009months), the median LRFS was not reached, and the median DMFS was 18.0\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This pilot study met its goal of demonstrating the tolerability of consolidation bevacizumab after hypo\u2010CCRT. Further investigation of antiangiogenic and immunotherapy combinations in LA\u2010NSCLC is warranted, while the potential for grade 3 respiratory toxicities should be taken into consideration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6381","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T02:40:46Z","timestamp":1691116846000},"page":"17638-17647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A pilot trial of consolidation bevacizumab after hypo\u2010fractionated concurrent chemoradiotherapy in patients with unresectable locally advanced non\u2010squamous non\u2010small\u2010cell lung cancer"],"prefix":"10.1002","volume":"12","author":[{"given":"LanQing","family":"Huo","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South 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