{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:01:23Z","timestamp":1791666083330,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lip, oral and pharyngeal cancers make up a small percentage of total cancer cases worldwide and have reported lower rates of cancer\u2010related deaths globally in 2020, but their 5\u2010year survival rate in either early or advanced stages is different. The study evaluated the global incidence, mortality, risk factors, and temporal trends by age, gender, and geographical locations of lip, oral cavity, and pharyngeal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Incidence and mortality rates were extracted from\n                      <jats:italic>Cancer Incidence in Five Continents<\/jats:italic>\n                      (\n                      <jats:italic>CI5<\/jats:italic>\n                      ) volumes I\u2010XI, the\n                      <jats:italic>Nordic Cancer Registries<\/jats:italic>\n                      (\n                      <jats:italic>NORDCAN<\/jats:italic>\n                      ), the\n                      <jats:italic>Surveillance, Epidemiology<\/jats:italic>\n                      , and\n                      <jats:italic>End Results<\/jats:italic>\n                      (\n                      <jats:italic>SEER<\/jats:italic>\n                      )\n                      <jats:italic>Program<\/jats:italic>\n                      , and the WHO IARC mortality database. Joinpoint regression was used to calculate the Average Annual Percentage Change to examine trends.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The highest incidence rates were found in Melanesia and South\u2010Central Asia and mortality rates were 8.2 and 7.5. Risk factors associated with incidence and mortality included HDI, tobacco use, alcohol consumption, poor diet, and chronic health conditions such as hypertension. Increasing trends of incidence and mortality were observed in females from Malta; males aged 50 and above from the United Kingdom, and females aged 50 and above from Slovakia reporting the largest increase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although global incidence and mortality trends reported an overall decrease, significant increases were found for older age groups and female subjects. Incidence increase may be due to the growing prevalence of lifestyle, metabolic risk factors, and HPV infections, especially in developed countries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6391","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T02:27:23Z","timestamp":1690770443000},"page":"18153-18164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Disease burden, risk factors, and trends of lip, oral cavity, pharyngeal cancers: A global analysis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-4443","authenticated-orcid":false,"given":"Junjie","family":"Huang","sequence":"first","affiliation":[{"name":"Faculty of Medicine The Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong  Hong Kong Special Administrative Region China"},{"name":"Centre for Health Education and Health Promotion, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-0569","authenticated-orcid":false,"given":"Sze Chai","family":"Chan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Ko","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6870-7553","authenticated-orcid":false,"given":"Veeleah","family":"Lok","sequence":"additional","affiliation":[{"name":"Department of Global Public Health Karolinska Institute, Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2064-8440","authenticated-orcid":false,"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Suzhou Industrial Park Monash Research Institute of Science and Technology  Suzhou China"},{"name":"The School of Public Health and Preventive Medicine Monash University  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The First Affiliated Hospital, School of Medicine, Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2179-6365","authenticated-orcid":false,"suffix":"III","given":"Don E.","family":"Lucero\u2010Prisno","sequence":"additional","affiliation":[{"name":"Department of Global Health and Development London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-2218","authenticated-orcid":false,"given":"Wanghong","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Public Health, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Jie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Global Health School of Public Health, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1135-0471","authenticated-orcid":false,"given":"Edmar","family":"Elcarte","sequence":"additional","affiliation":[{"name":"University of the Philippines  Manila the Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7754-0206","authenticated-orcid":false,"given":"Mellissa","family":"Withers","sequence":"additional","affiliation":[{"name":"Department of Population and Health Sciences Institute for Global Health, University of Southern California  Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7706-9370","authenticated-orcid":false,"given":"Martin C. S.","family":"Wong","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong  Hong Kong Special Administrative Region China"},{"name":"Centre for Health Education and Health Promotion, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong Special Administrative Region China"},{"name":"Department of Global Health School of Public Health, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"NCD Global Health Research Group, Association of Pacific Rim Universities (APRU)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.06.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.18486"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.11.094"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk179"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0983"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.018"},{"key":"e_1_2_8_9_1","first-page":"1","article-title":"Personal habits and indoor combustions. Volume 100 E. a review of human carcinogens","volume":"100","year":"2012","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.11.017"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600975"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23319"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2057178X17701517"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/2057178X17726455"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519894963"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21384"},{"key":"e_1_2_8_17_1","volume-title":"International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD\u201010) 2016","author":"World Health Organisation","year":"2016"},{"key":"e_1_2_8_18_1","volume-title":"Global Health Observatory Data Repository","author":"World Health Organization","year":"2016"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/02763869.2019.1693231"},{"key":"e_1_2_8_20_1","unstructured":"U.S. Department of Health and Human Services NIoH.Surveillance Epidemiology and End Results (SEER) Program.2020. Accessed May 10 2020.https:\/\/seer.cancer.gov\/about\/"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841861003782017"},{"key":"e_1_2_8_22_1","volume-title":"Cancer Incidence in Five Continents, Vol. XI (electronic version)","author":"Bray F","year":"2020"},{"key":"e_1_2_8_23_1","unstructured":"World Health Organization.WHO Mortality Database.2019. Accessed May 10 2020.https:\/\/www\u2010dep.iarc.fr\/whodb\/whodb.htm"},{"issue":"2","key":"e_1_2_8_24_1","first-page":"219","article-title":"Geographical observation on cancer mortality by selected sites on the basis of standardised death rate","volume":"48","author":"Segi M","year":"1957","journal-title":"Gan"},{"key":"e_1_2_8_25_1","unstructured":"BrayF FerlayJ.Age standardization.2022. Accessed January 31 2022.https:\/\/ci5.iarc.fr\/ci5\u2010xi\/pages\/chapter7.aspx"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3733"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.10.007"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.104551"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3126\/nje.v6i4.17255"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.15419\/bmrat.v3i10.129"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30382"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2012.00710.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28643"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.15419\/bmrat.v7i8.619"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC4402_01"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.0940"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2011.07853.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/tobaccocontrol-2021-056535"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32871"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(99)00070-6"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30697"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.6391","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:05:17Z","timestamp":1786968317000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,30]]},"references-count":40,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/cam4.6391"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6391","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,30]]},"assertion":[{"value":"2023-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}