{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:49:06Z","timestamp":1789559346694,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although cervical cancer is often characterized as preventable, its incidence continues to increase in low\u2010 and middle\u2010income countries, underscoring the need to develop novel therapeutics for this disease.This study assessed the distribution of fusion genes across cancer types and used an RNA\u2010based classification to divide cervical cancer patients with a poor prognosis into subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>RNA sequencing of 116 patients with cervical cancer was conducted. Fusion genes were extracted using StarFusion program. To identify a high\u2010risk group for recurrence, 65 patients who received postoperative adjuvant therapy were subjected to non\u2010negative matrix factorization to identify differentially expressed genes between recurrent and nonrecurrent groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified three cases with FGFR3\u2010TACC3 and one with GOPC\u2010ROS1 fusion genes as potential targets. A search of publicly available data from cBioPortal (21,789 cases) and the Center for Cancer Genomics and Advanced Therapeutics (32,608 cases) showed that the FGFR3 fusion is present in 1.5% and 0.6% of patients with cervical cancer, respectively. The frequency of the FGFR3 fusion gene was higher in cervical cancer than in other cancers, regardless of ethnicity. Non\u2010negative matrix factorization identified that the patients were classified into four Basis groups. Pathway enrichment analysis identified more extracellular matrix kinetics dysregulation in Basis 3 and more immune system dysregulation in Basis 4 than in the good prognosis group. CIBERSORT analysis showed that the fraction of M1 macrophages was lower in the poor prognosis group than in the good prognosis group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The distribution of FGFR fusion genes in patients with cervical cancer was determined by RNA\u2010based analysis and used to classify patients into clinically relevant subgroups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6415","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:51:06Z","timestamp":1691110266000},"page":"17835-17848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rare\n                    <scp>FGFR<\/scp>\n                    fusion genes in cervical cancer and transcriptome\u2010based subgrouping of patients with a poor prognosis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-4031","authenticated-orcid":false,"given":"Kengo","family":"Hiranuma","sequence":"first","affiliation":[{"name":"Division of Genome Biology National Cancer Center Research Institute  Tokyo Japan"},{"name":"Department of Obstetrics and Gynecology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Asami","sequence":"additional","affiliation":[{"name":"Division of Genome Biology National Cancer Center Research Institute  Tokyo Japan"},{"name":"Department of Obstetrics and Gynecology Showa University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi Kobayashi","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Genome Biology National Cancer Center Research Institute  Tokyo Japan"},{"name":"Department of Gynecology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0660-9987","authenticated-orcid":false,"given":"Naoya","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Shimada","sequence":"additional","affiliation":[{"name":"Division of Genome Biology National Cancer Center Research Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiko","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Division of Genome Biology National Cancer Center Research Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6141-9927","authenticated-orcid":false,"given":"Shu","family":"Yazaki","sequence":"additional","affiliation":[{"name":"Division of Genome Biology National Cancer Center Research Institute  Tokyo Japan"},{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0782-0922","authenticated-orcid":false,"given":"Erisa","family":"Fujii","sequence":"additional","affiliation":[{"name":"Division of Genome Biology National Cancer Center Research Institute  Tokyo Japan"},{"name":"Department of Gynecology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Sudo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikumi","family":"Kuno","sequence":"additional","affiliation":[{"name":"Department of Gynecology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Division of Medical AI Research and Development National Cancer Center Research Institute  Tokyo Japan"},{"name":"Cancer Translational Research Team RIKEN Center for Advanced Intelligence Project  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Hamamoto","sequence":"additional","affiliation":[{"name":"Division of Medical AI Research and Development National Cancer Center Research Institute  Tokyo Japan"},{"name":"Cancer Translational Research Team RIKEN Center for Advanced Intelligence Project  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Makinoshima","sequence":"additional","affiliation":[{"name":"Tsuruoka Metabolomics Laboratory National Cancer Center  Tsuruoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Showa University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuya","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Gynecology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kohno","sequence":"additional","affiliation":[{"name":"Division of Genome Biology National Cancer Center Research Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhisa","family":"Terao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Itakura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7569-7813","authenticated-orcid":false,"given":"Hiroshi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-7400","authenticated-orcid":false,"given":"Kouya","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Division of Genome Biology National Cancer Center Research Institute  Tokyo Japan"},{"name":"Department of Clinical Genomics National Cancer Center Research Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyasu","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gynecology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60022-7"},{"issue":"2","key":"e_1_2_14_4_1","first-page":"137","article-title":"Early cervical carcinoma: how to manage high\u2010risk patients after radical hysterectomy","volume":"85","author":"Samlal RA","year":"1999","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5387"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-021-0892-z"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12611"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq162"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-018-1351-y"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21386"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.10.022"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.12.019"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12881"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/13557858.2017.1373073"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-021-00244-2"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.406"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5846"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-017-0018-2"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3212"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.0027"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98527-2"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046331"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.828330"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.20243"},{"key":"e_1_2_14_25_1","first-page":"xiii, 94","volume-title":"The General Rules for Clinical and Pathological Management on Uterine Cervical Cancer, the","author":"Japan_society_of_obstetrics_and_gynecology","year":"2012"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky955"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1842-9"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3122"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0114-2"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4333"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23306"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-22-0417"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90139-0"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-010-0061-x"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-015-0806-7"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1351"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12563"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlz093"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8060614"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2004.08.007"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-013-0886-7"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2015.03.003"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.26.14352"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005345"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.632786"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8122112"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1220834"},{"key":"e_1_2_14_49_1","first-page":"110","article-title":"FIGHT\u2010101, a first\u2010in\u2010human study of potent and selective FGFR 1\u20103 inhibitor pemigatinib in pan\u2010cancer patients with FGF\/FGFR alterations and advanced malignancies","volume":"22","author":"Subbiah V","year":"2022","journal-title":"Ann Oncol"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02630"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02369-1"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0838"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz131"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.5587"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061215"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103028"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2021.108875"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.05.007"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgaa128"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.6415","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:03:46Z","timestamp":1786968226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,3]]},"references-count":58,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/cam4.6415"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6415","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,3]]},"assertion":[{"value":"2023-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}