{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:28:06Z","timestamp":1786969686164,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Studies comparing the effectiveness of either adjuvant oral uracil\u2010tegafur (UFT) or intravenous chemotherapy on early\u2010stage (stage I and II) non\u2010small cell lung cancer (NSCLC) patients treated with complete surgical treatment remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From January 2011 to December 2017, patients with early\u2010stage NSCLC (defined as tumor size &gt;3\u2009cm without mediastinal lymph node involvement or any distant metastasis) receiving either adjuvant oral UFT or intravenous chemotherapy after surgical resection were identified from the Taiwan Cancer Registry. Overall survival (OS) and relapse\u2010free survival (RFS) were the primary and secondary outcomes, respectively. Propensity matching was used for controlling confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 840 patients receiving adjuvant therapy after surgery (including 595 oral UFT and 245 intravenous chemotherapy) were enrolled. Before matching, patients using oral UFT had significantly longer OS (HR: 0.69, 95% CI: 0.49\u20130.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0387) and RFS (HR: 0.79, 95% CI: 0.61\u20130.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0392) than those with intravenous chemotherapy. A matched cohort of 352 patients was created using 1:1 propensity score\u2010matching. In the Cox regression analysis, the UFT and the matched chemotherapy groups had similar OS (HR: 0.80, 95% CI: 0.48\u20131.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.3753) and RFS (HR: 0.98, 95% CI: 0.72\u20131.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.9149). Among subgroup analysis, oral UFT use was associated with longer RFS among the subgroups of non\u2010drinker (HR: 0.66, 95% CI: 0.34\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0478) and patients with stage IB disease (HR: 0.67, 95% CI: 0.42\u20130.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0341).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This population\u2010based study in the real\u2010world setting of Taiwan demonstrates comparable effectiveness between oral UFT and intravenous chemotherapy in terms of clinical outcomes for early\u2010stage NSCLC patients after surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6440","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T02:01:37Z","timestamp":1691632897000},"page":"17993-18004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oral uracil\u2013tegafur compared with intravenous chemotherapy as adjuvant therapy for resected early\u2010stage non\u2010small cell lung cancer patients"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3486-2293","authenticated-orcid":false,"given":"Sheng\u2010Kai","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Medicine National Taiwan University Cancer Center  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital, Hsinchu Branch  Hsinchu 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