{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:28:10Z","timestamp":1786969690272,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We evaluated the frequency of genomic testing and treatment patterns by age category in patients with newly diagnosed (ND) acute myeloid leukemia (AML) treated in both academic\u2010 and community\u2010based health systems within a single Midwestern State.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of data from the Indiana University Health System Enterprise Data Warehouse and two local cancer registries, of 629 patients aged \u226518\u2009years with ND AML during 2011\u20132018. Primary outcome variables were, proportion of patients with genomic analysis and frequency of mutations. Chemotherapy was categorized as \u201cstandard induction\u201d or \u201cother chemotherapy\u201d\/targeted therapy, and hypomethylating agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 13% of ND AML patients between 2011 and 2018 had evidence of a genomic sequencing report with a demonstrated increase to 37% since 2016. Genomic testing was more likely performed in patients: aged \u226460\u2009years than &gt;60\u2009years (45% vs. 30%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), treated in academic versus community hospitals (44% vs. 26%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), and in chemotherapy recipients than non\u2010therapy recipients (46% vs. 19%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Most common mutations were\n                      <jats:italic>ASXL1<\/jats:italic>\n                      ,\n                      <jats:italic>NPM1<\/jats:italic>\n                      , and\n                      <jats:italic>FLT3<\/jats:italic>\n                      . Patients \u226575\u2009years had highest proportion (46%) of multiple (\u22653) mutations. Overall, 31.2% of patients with AML did not receive any therapy for their disease. This subgroup was older than chemotherapy recipients (mean age: 71.4 vs. 55.7\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and was highest (66.2%) in patients \u226575\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results highlight the unmet medical need to increase access to genomic testing to afford treatment options, particularly to older AML patients in the real\u2010world setting, in this new era of targeted therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6442","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T03:30:30Z","timestamp":1693193430000},"page":"18368-18380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Real\u2010world genomic testing and treatment patterns of newly diagnosed adult acute myeloid leukemia patients within a comprehensive health system"],"prefix":"10.1002","volume":"12","author":[{"given":"John C.","family":"Byrd","sequence":"first","affiliation":[{"name":"University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Gatz","sequence":"additional","affiliation":[{"name":"Regenstrief Institute  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia Lim","family":"Louis","sequence":"additional","affiliation":[{"name":"Regenstrief Institute  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice S.","family":"Mims","sequence":"additional","affiliation":[{"name":"The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Borate","sequence":"additional","affiliation":[{"name":"The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley O.","family":"Yocum","sequence":"additional","affiliation":[{"name":"The Leukemia and Lymphoma Society  Rye Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-5202","authenticated-orcid":false,"given":"Theophilus J.","family":"Gana","sequence":"additional","affiliation":[{"name":"Biopharmatech Consulting, Inc.  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