{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:48:33Z","timestamp":1773326913247,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2022NSFSC0806"],"award-info":[{"award-number":["2022NSFSC0806"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our study was performed to evaluate the significance of countable and treatable metastatic liver disease (CTMLD) in patients with gallbladder carcinoma (GBC) after curative\u2010intent surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Resected GBC patients between September 2010 and January 2021 were reviewed. Comparative analyses between patients with CTMLD and those without it were performed. A propensity score matching analysis was conducted for further validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 326 resected GBC patients were identified (33 with CTMLD). A significantly higher preoperative CA199 level was detected in those with CTMLD (<jats:italic>p<\/jats:italic>\u2009=\u20090.0160). Significantly higher incidences of major hepatectomy (<jats:italic>p<\/jats:italic>\u2009=\u20090.0010), lymph node metastasis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), direct liver invasion (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), moderate to poor differentiation status (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and T3\u20134 disease (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) were detected in patients with CTMLD. Even sharing comparable surgical margin status, patients with CTMLD still shared a significantly higher recurrence rate (93.9% vs. 57.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) as well as a significantly higher recurrence rate within 6\u2009months after surgery (63.6% vs. 14.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). A significantly worse overall survival (median survival time: 12 vs. 33\u2009months, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) or disease\u2010free survival (median recurrence\u2010free time: 6 vs. 30\u2009months, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) was acquired in patients with CTMLD. After matching, a significantly higher early recurrence rate was still detected. Adjuvant chemotherapy seemed to have survival benefit for patients with CTMLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CTMLD was an indicator of advanced disease and served as an independent predictor of early recurrence among resected GBC patients. Whether curative\u2010intent surgery is superior to nonsurgical treatment among GBC patients with CTMLD remains to be explored in future prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6450","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T06:39:45Z","timestamp":1691735985000},"page":"18503-18515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative\u2010intent surgery: A 10\u2010year experience in China"],"prefix":"10.1002","volume":"12","author":[{"given":"Tian\u2010Run","family":"Lv","sequence":"first","affiliation":[{"name":"Department of General Surgery, Biliary Track Surgery West China Hospital of Sichuan University  Chengdu 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