{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:48Z","timestamp":1786977408913,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune checkpoint inhibitors (ICIs) have emerged as a standard treatment for various malignancies. However, research indicates blocking the immune checkpoint pathway may exacerbate atherosclerotic lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to investigate whether ICI therapy increases the risk of arterial thromboembolic events (ATEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted on patients with histologically confirmed cancer at our institution between 2018 and 2021, using the propensity score matching method. The primary endpoint was ATEs occurrence, comprising acute coronary syndrome, stroke\/transient ischemic attack, and peripheral arterial thromboembolism. Subgroup analyses assessed whether the ICI treatment effect on ATEs varied over time by limiting the maximum follow\u2010up duration. Logistic regression analysis identified ATE risk factors in ICI\u2010treated patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, the ICI group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092877) demonstrated an ATEs risk 2.01 times higher than the non\u2010ICI group (RR, 2.01 [95% CI (1.61\u20132.51)];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Subgroup analysis revealed no significant increase in ATEs risk for ICI\u2010treated patients within 1\u2009year (Limited to a max 9\u2010month follow\u2010up,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.075). However, ATEs risk in the ICI group rose by 41% at 1\u2009year (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) and 97% at 4\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001). Age, diabetes, hypertension, peripheral atherosclerosis, atrial fibrillation, chronic ischemic heart disease, distant cancer metastasis, and ICI treatment cycles contributed to ATEs risk elevation in ICI\u2010treated patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ICI\u2010treated patients may exhibit a higher risk of ATEs, especially after 1\u2009year of treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6455","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T01:33:56Z","timestamp":1692408836000},"page":"18531-18541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of immune checkpoint inhibitors therapy with arterial thromboembolic events in cancer patients: A retrospective cohort study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0112-5093","authenticated-orcid":false,"given":"Jie","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Cardio\u2010Oncology Chongqing University Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Oncology Chongqing University Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanlong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine Chongqing University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Oncology Chongqing University Cancer Hospital  Chongqing 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Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dairong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Chongqing University Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Oncology Chongqing University Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Oncology Chongqing University Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"The Cancer Research Institute.Immunomodulators:Checkpoint Inhibitors Cytokines Agonists and 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