{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:28:36Z","timestamp":1781731716398,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA022453"],"award-info":[{"award-number":["P30CA022453"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA199240\u201004S1"],"award-info":[{"award-number":["CA199240\u201004S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 CA199240"],"award-info":[{"award-number":["U01 CA199240"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Pre\u2010existing comorbidities play an important role in choice of cancer treatment. We retrospectively evaluated the relationship between pre\u2010existing comorbidities and receipt of local and systemic therapy in a cohort of Black women with Stage I\u2013III breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population for analysis included 1169 women with Stage I\u2013III disease enrolled in the Detroit Research on Cancer Survivors (ROCS) cohort. Information on comorbidities, socio\u2010demographic, and clinical variables were obtained from self\u2010reported questionnaires and the cancer registry. Comorbidities were analyzed individually, and comorbidity burden was categorized as low (0\u20131), moderate (2\u20133) or high (\u22654). We used logistic regression analysis to evaluate factors associated with receipt of local treatment (surgery \u00b1 radiation; <jats:italic>N<\/jats:italic>\u2009=\u20091156), hormonal (<jats:italic>N<\/jats:italic>\u2009=\u2009848), and chemotherapy (<jats:italic>N<\/jats:italic>\u2009=\u2009680). Adjusted models included variables selected a priori that were significant predictors in univariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Receipt of treatment was categorized into local (82.6%), hormonal (73.7%), and\/or chemotherapy (79.9%). Prior history of arthritis and depression were both associated with a lower likelihood to receive local treatment, [odds ratio (OR), 95% confidence interval (CI), 0.66, 0.47\u20130.93, and 0.53, 0.36\u20130.78], respectively. Obesity was associated with higher likelihood of receiving hormonal therapy (OR: 1.64, 95% CI: 1.19, 2.26), and heart failure a lower likelihood (OR: 0.46, 95% CI: 0.23, 0.90). Older age (P<jats:sub>trend<\/jats:sub>\u2009&lt;0.01) and increasing co\u2010morbidity burden (P<jats:sub>trend<\/jats:sub>\u2009=\u20090.02) were associated with lower likelihood of receiving chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>History of prior co\u2010morbidities has a potentially detrimental influence on receipt of recommended cancer\u2010directed treatment among women with Stage I\u2013III breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6456","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T07:25:36Z","timestamp":1691738736000},"page":"19021-19032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of preexisting comorbidities on receipt of cancer therapy among women with Stage <scp>I\u2013III<\/scp> breast cancer in the Detroit Research on Cancer Survivors cohort"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7664-6946","authenticated-orcid":false,"given":"Sreejata","family":"Raychaudhuri","sequence":"first","affiliation":[{"name":"Department of Medical Oncology\/Hematology University of Pittsburgh, Hillman Cancer Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn M.","family":"Kyko","sequence":"additional","affiliation":[{"name":"Department of Oncology Karmanos Cancer Institute at Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie J.","family":"Ruterbusch","sequence":"additional","affiliation":[{"name":"Department of Oncology Karmanos Cancer Institute at Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie S.","family":"Pandolfi","sequence":"additional","affiliation":[{"name":"Department of Oncology Karmanos Cancer Institute at Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Beebe\u2010Dimmer","sequence":"additional","affiliation":[{"name":"Department of Oncology Karmanos Cancer Institute at Wayne State University  Detroit Michigan USA"},{"name":"Population Studies and Disparities Research Program Karmanos Cancer Institute  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann G.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Oncology Karmanos Cancer Institute at Wayne State University  Detroit Michigan USA"},{"name":"Population Studies and Disparities Research Program Karmanos Cancer Institute  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3237-6761","authenticated-orcid":false,"given":"Michael 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