{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:27:54Z","timestamp":1768876074975,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We previously reported results of a pooled analysis of two zanubrutinib studies in relapsed or refractory (R\/R) MCL showing better survival outcomes when zanubrutinib is used in second\u2010line versus later\u2010line. Here, we present an updated pooled analysis with a longer follow\u2010up of 35.2\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were pooled from two studies\u2014BGB\u20103111\u2010AU\u2010003 (NCT02343120) and BGB\u20103111\u2010206 (NCT03206970) of zanubrutinib in R\/R MCL. The patients were divided into two groups based on the treatment line of zanubrutinib: the second\u2010line and the later\u2010line group. The inverse propensity score weighting method was used to balance the baseline covariates between the groups. The primary outcome was overall survival (OS). Secondary outcomes included progression\u2010free survival (PFS), PFS, and OS rates, objective response rate (ORR), duration of response (DOR), and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 112 pooled patients, 41 (36.6%) patients received zanubrutinib as second\u2010line and 71 (63.4%) patients as later\u2010line therapy. After weighting, OS was significantly improved in the second\u2010line versus later\u2010line group (HR, 0.459 [95% CI: 0.215, 0.98]; <jats:italic>p<\/jats:italic>\u2009=\u20090.044) with median OS not estimable in both groups. The PFS was similar between the two groups (HR, 0.78 [95% CI: 0.443, 1.373]; <jats:italic>p<\/jats:italic>\u2009=\u20090.389) but with numerically longer median PFS in the second\u2010line versus later\u2010line group (27.8 vs. 22.1\u2009months). ORR was numerically higher in the second\u2010line versus later\u2010line (88.6% vs. 85.7%), and DOR was similar between the two groups (25.2 vs. 25.1\u2009months). Zanubrutinib showed a similar safety profile in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Zanubrutinib in second\u2010line treatment was associated with significantly improved OS compared with later\u2010line treatment of R\/R MCL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6473","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T14:34:44Z","timestamp":1694702084000},"page":"18643-18653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010term outcomes of second\u2010line versus later\u2010line zanubrutinib treatment in patients with relapsed\/refractory mantle cell lymphoma: An updated pooled analysis"],"prefix":"10.1002","volume":"12","author":[{"given":"Yuqin","family":"Song","sequence":"first","affiliation":[{"name":"Peking University Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5467-1377","authenticated-orcid":false,"given":"Keshu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehui","family":"Zou","sequence":"additional","affiliation":[{"name":"Institute of Hematology &amp; Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dengju","family":"Li","sequence":"additional","affiliation":[{"name":"Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4438-2544","authenticated-orcid":false,"given":"Jianda","family":"Hu","sequence":"additional","affiliation":[{"name":"Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Yang","sequence":"additional","affiliation":[{"name":"The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huilai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Medical University Cancer Institute and Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ji","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-7477","authenticated-orcid":false,"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Jin","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University College of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Lv","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru","family":"Feng","sequence":"additional","affiliation":[{"name":"Nanfang Hospital of Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujun","family":"Gao","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1592-1932","authenticated-orcid":false,"given":"Daobin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantine S.","family":"Tam","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre, St. Vincent's Hospital University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Simpson","sequence":"additional","affiliation":[{"name":"North Shore Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9748-5486","authenticated-orcid":false,"given":"Michael","family":"Wang","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tycel J.","family":"Phillips","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0308-6458","authenticated-orcid":false,"given":"Stephen","family":"Opat","sequence":"additional","affiliation":[{"name":"Monash Health, Monash University  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Fang","sequence":"additional","affiliation":[{"name":"BeiGene (Beijing) Co., Ltd.  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