{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T05:04:18Z","timestamp":1775970258310,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003089"],"award-info":[{"award-number":["82003089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recently, chemotherapy plus immunotherapy has achieved remarkable efficacy in lung squamous cell carcinoma (LUSC). However, some patients, especially frail people, cannot tolerate full\u2010dose chemotherapy in the real world. To reduce toxicity, appropriate dose reduction in chemotherapy is necessary. Therefore, this study aimed to demonstrate the efficacy and safety of reduced\u2010dose chemotherapy plus immunotherapy in LUSC patients in the real world.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A real\u2010world observational study was conducted concerning patients who received chemotherapy plus immunotherapy in our situation. The primary endpoints were objective response rate (ORR) and disease control rate (DCR), and the secondary endpoints were progression\u2010free survival (PFS), overall survival (OS), and toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between December 2018 and January 2022, 110 patients were enrolled, of whom 54 patients were chemotherapy reduced\u2010dose group and 56 patients were chemotherapy standard\u2010dose group. The ORR in the reduced\u2010dose group is similar to standard\u2010dose group (85.19% vs. 71.43%, <jats:italic>p<\/jats:italic>\u2009=\u20090.082). Similar DCR were observed (100% vs. 94.64%, <jats:italic>p<\/jats:italic>\u2009=\u20090.086). Median PFS was 12\u2009months in the reduced\u2010dose group and standard\u2010dose group, respectively. Median OS was 15\u2009months and 16\u2009months in the reduced\u2010dose group and standard\u2010dose group, respectively. We reported a lower incidence of grade 3\u20134 toxicity in the reduced\u2010dose group compared with standard\u2010dose group (27.78% vs. 42.86%, <jats:italic>p<\/jats:italic>\u2009=\u20090.100). The major toxic reactions were better alleviated in the reduced\u2010dose group than in the standard\u2010dose group, especially in the thrombocytopenia (<jats:italic>p<\/jats:italic>\u2009=\u20090.044), peripheral nerve damage (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), gastrointestinal reactions (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and fatigue (<jats:italic>p<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The modified regimen with attenuated doses of chemotherapy in combination with immunotherapy was effective and well tolerated in patients with LUSC. The efficacy of this modified regimen is similar to that of the full\u2010dose regimen.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6478","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T13:44:15Z","timestamp":1694094255000},"page":"18679-18690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and safety of reduced\u2010dose chemotherapy plus immunotherapy in patients with lung squamous cell carcinoma: A <scp>real\u2010world<\/scp> observational study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1375-5560","authenticated-orcid":false,"given":"Ganlu","family":"Ouyang","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Cancer Center, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Lung Cancer Center, West China Hospital Sichuan University  Chengdu Sichuan 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Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Center, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Lung Cancer Center, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Center, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Lung Cancer Center, West China Hospital Sichuan University  Chengdu Sichuan 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