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However, its role in disease severity and mortality is less clear. We aimed to ascertain associations between <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>, severity and <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>\u2010specific mortality in a hospital\u2010based cohort of 5354 women with prospective information on <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>. We included women diagnosed at Guy's and St Thomas\u2019 <jats:styled-content style=\"fixed-case\">NHS<\/jats:styled-content> Foundation Trust between 1975 and 2012 (<jats:italic>n<\/jats:italic>\u00a0=\u00a05354). <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> severity was defined and categorized as good, moderate, and poor prognosis. Data on <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>\u2010specific mortality was obtained from the National Cancer Registry and medical records. Associations between <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> and disease severity or <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>\u2010specific mortality were evaluated using proportional odds models and Cox proportional hazard regression models, respectively. Available data allowed adjustment for potential confounders (e.g., treatment, socioeconomic status, and ethnicity). <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> of any degree was not associated with disease severity at time of diagnosis (adjusted proportional <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.00 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.85 to 1.17]), which remained true also after stratification by period of diagnosis. <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> was not associated with <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>\u2010mortality <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>: 0.99 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.93 to 1.05). We did not find evidence to support an association between <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> and severity and <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>\u2010specific mortality. Our results indicate that clinical management should not differ between women with and without <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>, when the underlying mutation is unknown.<\/jats:p>","DOI":"10.1002\/cam4.648","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T14:07:47Z","timestamp":1453471667000},"page":"942-949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Family history of breast cancer and its association with disease severity and mortality"],"prefix":"10.1002","volume":"5","author":[{"given":"Jennifer C.","family":"Melvin","sequence":"first","affiliation":[{"name":"Faculty of Life Sciences and Medicine Division of Cancer Studies Cancer Epidemiology Group King's College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahyu","family":"Wulaningsih","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Medicine Division of Cancer Studies Cancer Epidemiology Group King's College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zac","family":"Hana","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Medicine Division of Cancer Studies Cancer Epidemiology Group King's College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnie D.","family":"Purushotham","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Medicine Division of Cancer Studies Section of Research Oncology King's College London  London United Kingdom"},{"name":"Guy's and St. Thomas\u2019 NHS Foundation Trust  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Pinder","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Medicine Division of Cancer Studies Section of Research Oncology King's College London  London United Kingdom"},{"name":"Guy's and St. Thomas\u2019 NHS Foundation Trust  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Fentiman","sequence":"additional","affiliation":[{"name":"Regional Cancer Centre Uppsala\/Orebro  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Gillett","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Medicine Division of Cancer Studies Section of Research Oncology King's College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Mera","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Medicine Division of Cancer Studies Cancer Epidemiology Group King's College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Medicine Division of Cancer Studies Cancer Epidemiology Group King's College London  London United Kingdom"},{"name":"Research Oncology Guy's Hospital  London United Kingdom"},{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieke","family":"Van Hemelrijck","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Medicine Division of Cancer Studies Cancer Epidemiology Group King's College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1563","article-title":"A comprehensive evaluation of family history and breast cancer risk","volume":"270","author":"Slattery M. 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