{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:16:50Z","timestamp":1774685810835,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The COVID\u201019 pandemic led to care disruptions across the cancer continuum. It is unknown if immunosuppressed patients with cancer, who may be at higher risk for complications of SARS\u2010CoV\u20102 infection, are disproportionately impacted. Thus, we aimed to compare delays in cancer treatment initiation between people living with HIV (PLWH) and cancer, the general cancer population (GCP), and patients with cancer and a history of solid organ transplant (SOT). Comparisons were made across the period 2\u2009years preceding the pandemic versus the first year of the pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from a real\u2010world electronic health record\u2010derived de\u2010identified database (2018\u20132021) comprised of US patients with cancer from 800 sites of care across the country. We included patients with 19 different cancer types. We calculated time to cancer treatment initiation (TTI) as the difference between the date of cancer diagnosis and the earliest date that cancer treatment was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample included 181 PLWH, 65,073 GCP patients, and 195 patients with a SOT. Difference\u2010in\u2010difference regression models adjusted for age, sex, and presence of metastatic disease at cancer diagnosis revealed a significant increase in delayed TTI among PLWH compared to the GCP during COVID\u201019 versus prior to COVID\u201019, with delays increasing by approximately 1\u2009month during the pandemic (DID: 32.6\u2009days [8.9\u201356.3]; <jats:italic>p<\/jats:italic>\u2009=\u20090.007). The increase in TTI for PLWH was observed across treatment modalities, including surgery (DID: 55.1 [28.8\u201381.3], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and systemic therapy (DID: 30.4 [4.6\u201356.3], <jats:italic>p<\/jats:italic>\u2009=\u20090.021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions\/Relevance<\/jats:title><jats:p>PLWH experienced significant delays in cancer treatment initiation after diagnosis during the first year of COVID\u201019, delays that may negatively impact cancer outcomes. These data warrant patient and provider attention as the pandemic continues to impact the US healthcare system.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6489","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T13:05:27Z","timestamp":1694783127000},"page":"18717-18728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cancer treatment delays among cancer patients living with <scp>HIV<\/scp> during the <scp>COVID<\/scp>\u201019 pandemic in the United States"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6925-359X","authenticated-orcid":false,"given":"Ashley","family":"Khouri","sequence":"first","affiliation":[{"name":"University of Utah School of Medicine  Salt Lake City Utah USA"},{"name":"Huntsman Cancer Institute  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3690-3848","authenticated-orcid":false,"given":"Jessica Y.","family":"Islam","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Program H. Lee Moffitt Cancer Center &amp; Research Institute  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan W.","family":"Van\u00a0Bibber","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Program H. Lee Moffitt Cancer Center &amp; Research Institute  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna E.","family":"Coghill","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Program H. Lee Moffitt Cancer Center &amp; Research Institute  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gita","family":"Suneja","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute  Salt Lake City Utah USA"},{"name":"Department of Radiation Oncology University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2020-0213"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/Cci.20.00134"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/Cci.20.00068"},{"key":"e_1_2_10_5_1","unstructured":"Administration U. S. F. D.FDA drug shortages. 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