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A single\u2010nucleotide polymorphism (SNP) array was used to determine genetic loci that increase susceptibility to OPSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed the allele frequencies of 664,994 autosomal SNPs in 659 HNSCC cases; 7 SNPs scattered in loci of chromosomes 5, 7, 9, 11, and 19 were significant in genome\u2010wide association analysis (<jats:italic>Pc<\/jats:italic>\u2009&lt;\u20091.0669\u2009\u00d7\u200910<jats:sup>\u22127<\/jats:sup>). In OPSCCs (<jats:italic>n<\/jats:italic>\u2009=\u2009331), two clustered regions in chromosomes 4 and 6 were significantly different from the controls. We successfully identified a missense alteration of the SNP region in alcohol dehydrogenase 1B (<jats:italic>ADH1B<\/jats:italic>) (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/genome.ucsc.edu\">https:\/\/genome.ucsc.edu<\/jats:ext-link>; hg38); the top correlated locus was rs1229984 (<jats:italic>p<\/jats:italic>\u2009=\u20091\u2009\u00d7\u200910<jats:sup>\u221211<\/jats:sup>). Adjusted for environmental exposure, including smoking, alcohol, and areca quid, a region in chromosome 12, related to alcohol metabolism, was found to independently increase the susceptibility to OPSCC. The <jats:italic>ADH1B<\/jats:italic> rs1229984 AA genotype had better overall survival compared to the AG and GG genotypes (<jats:italic>p<\/jats:italic>\u2009=\u20090.042) in OPSCC. The GG genotype in rs1229984 was significantly associated with a younger age of onset than other genotypes (<jats:italic>p<\/jats:italic>\u2009=\u20090.001 and &lt;0.001, respectively) in OPSCC patients who consumed alcohol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>ADH1B<\/jats:italic> was an important genetic locus that significantly correlated with the development of OPSCCs and patient survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6506","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T16:24:49Z","timestamp":1694708689000},"page":"19174-19187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Single\u2010nucleotide polymorphism at alcohol dehydrogenase 1B: A susceptible gene marker in oro\u2010\/hypopharyngeal cancers from genome\u2010wide association study"],"prefix":"10.1002","volume":"12","author":[{"given":"Hui\u2010Tzu","family":"Chien","sequence":"first","affiliation":[{"name":"Department of Nutrition and Health Sciences Chang Gung University of Science and Technology  Taoyuan Taiwan"},{"name":"Geriatric and Long\u2010Term Care Research Center Chang Gung University of Science and Technology  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Lung","family":"Tsai","sequence":"additional","affiliation":[{"name":"Genomic Medicine Research Core Laboratory Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Kuan","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Chang Gung Memorial Hospital, Keelung Branch  Keelung Taiwan"},{"name":"Medical College, Chang Gung Memorial Hospital  Taoyuan 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