{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:22:20Z","timestamp":1787649740115,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["rc2023"],"award-info":[{"award-number":["rc2023"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of family and personal cancer history and emotional factors, such as depression and anxiety, on disease representation has received limited attention in studies investigating the development of cancer\u2010related worry and risk perception within the context of genetic counseling. The current study endeavors to fill this gap by exploring the extent to which depression and anxiety influence cancer worry and risk perception, and the role of health care\u2010related fear as potential mediator in this relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A sample of 178 women who underwent their first genetic counseling for breast\/ovarian cancer, 52% of whom had previous cancer diagnoses, completed questionnaires assessing sociodemographic and clinical information, emotional distress in terms of anxiety and depression, cancer\u2010related worry, risk perception, and health care\u2010related fears.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Results of mediation analyses showed that cancer\u2010related worry and risk perception increased with rising levels of depression and anxiety, with health care\u2010related fears acting as a mediator in the relationship of depression and anxiety with cancer worry and risk perception. Covariate analysis revealed that previous cancer diagnosis increases cancer\u2010related worry but not risk perception, while the number of family members affected by cancer increases both outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings emphasize the need for a holistic approach in genetic counseling and have implications for the clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6518","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T12:25:29Z","timestamp":1694694329000},"page":"19215-19224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Breast\/ovarian cancer genetic counseling: Do anxiety, depression, and health care\u2010related fears influence cancer worry and risk perception?"],"prefix":"10.1002","volume":"12","author":[{"given":"Anita","family":"Caruso","sequence":"first","affiliation":[{"name":"Psychology Unit IRCCS \u201cRegina Elena\u201d National Cancer Institute  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Maggi","sequence":"additional","affiliation":[{"name":"Psychology Unit IRCCS \u201cRegina Elena\u201d National Cancer Institute  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Vigna","sequence":"additional","affiliation":[{"name":"Psychology Unit IRCCS \u201cRegina Elena\u201d National Cancer Institute  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Savarese","sequence":"additional","affiliation":[{"name":"Department of Oncology IRCCS \u201cRegina Elena\u201d National Cancer Institute  Rome 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