{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:20:08Z","timestamp":1790306408202,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017683","name":"Frederick A. DeLuca Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017683","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Polycythemia vera (PV) and essential thrombocythemia (ET) are linked to increased risk of cardiovascular morbidity and mortality. In addition to the reduction in of arterial thrombotic events, statins may prevent venous thrombosis including among patients with cancer. As previous registry\u2010 and claims\u2010based studies revealed that the use of statins may improve the survival of patients with various malignancies we evaluated their impact on outcomes of older adults with PV and ET.<\/jats:p><\/jats:sec>Methods<\/jats:title>We identified 4010 older adults (aged 66\u201399\u2009years at diagnosis) with PV (n<\/jats:italic>\u2009=\u20091809) and ET (n<\/jats:italic>\u2009=\u20092201) in a population\u2010based cohort study using the Surveillance, Epidemiology, and End Results\u2010Medicare database with median follow\u2010up of 3.92 (interquartile range: 2.58\u20135.75) years. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) approaches were utilized to assess potential association between statins and overall survival. Multivariable competing risk models with death as a competing risk were used to evaluate possible relationship between statins and the incidence of thrombosis.<\/jats:p><\/jats:sec>Results<\/jats:title>55.8% of the patients used statins within the first year after PV<\/jats:styled-content>\/ET<\/jats:styled-content> diagnosis, and statin use was associated with a 22% reduction in all\u2010cause mortality (PSM<\/jats:styled-content>: hazard ratio [HR<\/jats:styled-content>]\u2009=\u20090.78, 95% confidence interval [CI<\/jats:styled-content>]: 0.63\u20130.98, p<\/jats:italic>\u2009=\u20090.03; IPTW<\/jats:styled-content>: HR<\/jats:styled-content>\u2009=\u20090.79, 95% CI<\/jats:styled-content>: 0.64\u20130.97, p<\/jats:italic>\u2009=\u20090.03). Statins also reduced the risk of thrombosis in this patient population (PSM<\/jats:styled-content>: HR<\/jats:styled-content>\u2009=\u20090.63, 95% CI<\/jats:styled-content>: 0.51\u20130.78, p<\/jats:italic>\u2009<\u20090.01; IPTW<\/jats:styled-content>: HR<\/jats:styled-content>\u2009=\u20090.57, 95% CI<\/jats:styled-content>: 0.49\u20130.66, p<\/jats:italic>\u2009<\u20090.01) as well as in PV<\/jats:styled-content> and ET<\/jats:styled-content> subgroups.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These findings suggest that it may be important to incorporate statins into the therapeutic strategy for older adults with PV and ET.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6528","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T08:53:39Z","timestamp":1694595219000},"page":"18889-18900","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Statin use, survival and incidence of thrombosis among older patients with polycythemia vera and essential thrombocythemia"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3657-778X","authenticated-orcid":false,"given":"Nikolai A.","family":"Podoltsev","sequence":"first","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine Yale School of Medicine New Haven Connecticut USA"},{"name":"Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center Yale University New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center Yale University New Haven Connecticut USA"},{"name":"Department of Chronic Disease Epidemiology Yale School of Public Health New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8542-2944","authenticated-orcid":false,"given":"Rory M.","family":"Shallis","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine Yale School of Medicine New Haven Connecticut USA"},{"name":"Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center Yale University New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Stempel","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine Yale School of Medicine New Haven Connecticut USA"},{"name":"Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center Yale University New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyang","family":"Di","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine Yale School of Medicine New Haven Connecticut USA"},{"name":"Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center Yale University New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Neparidze","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine Yale School of Medicine New Haven Connecticut USA"},{"name":"Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center Yale University New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer M.","family":"Zeidan","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine Yale School of Medicine New Haven Connecticut USA"},{"name":"Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center Yale University New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7071-6475","authenticated-orcid":false,"given":"Scott F.","family":"Huntington","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine Yale School of Medicine New Haven Connecticut USA"},{"name":"Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center Yale University New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1827-5032","authenticated-orcid":false,"given":"Smith","family":"Giri","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Hull","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Internal Medicine Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Gore","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Ma","sequence":"additional","affiliation":[{"name":"Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center Yale University New Haven Connecticut USA"},{"name":"Department of Chronic Disease Epidemiology Yale School of Public Health New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2022.04.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008259"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03625-x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.6652"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0046"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0077-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.039"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60367-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.145334"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(16)30184-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2017.10.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.106.128793"},{"issue":"112","key":"e_1_2_9_15_1","first-page":"413","article-title":"Statins as anti\u2010cancer therapy; can we translate preclinical and epidemiologic data into clinical benefit?","volume":"20","author":"Chae YK","year":"2015","journal-title":"Discov Med"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.6"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-18-1194"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171137"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121783"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.8981"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.10.008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.3482"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0808"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/4938539","article-title":"Statins are associated with improved survival of patients with gastric cancer: a systematic review and meta\u2010analysis","volume":"2022","author":"Yuan M","year":"2022","journal-title":"Int J Clin Pract"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.03.028"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30185"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023009784"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2005.12.018"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-394775"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/102476"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lrr.2016.06.004"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-03950-6"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-013-0310-1"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2012.12.005"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199801000-00004"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2265"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-022-04802-1"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023009818"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.05.014"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12103"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.102"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2013.01.004"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.07.009"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-348144"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-348755"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0353"},{"key":"e_1_2_9_49_1","unstructured":"Force USPST.USPSTF.2016. Accessed August 9 2023.https:\/\/www.uspreventiveservicestaskforce.org\/"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.003"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-263319"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T05:39:32Z","timestamp":1705642772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":50,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/cam4.6528"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6528","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"2023-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}