{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:05:19Z","timestamp":1792123519441,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Comprehensive molecular subtyping of diffuse large B\u2010cell lymphoma (DLBCL) through genetic profiling has broadened our understanding of DLBCL biology. In this study, we investigated whether DLBCL, not otherwise specified (NOS) shows differences in mutational patterns depending on the primary organ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Panel\u2010based next\u2010generation sequencing was performed on 345 DLBCL from various primary organs, and patterns of mutations according to primary organs were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DLBCL showed a characteristic mutational signature in several primary organs. Among them, the mutational pattern of DLBCL in the breast and ileocecal area was particularly different from that of other DLBCL NOS. In breast DLBCL, <jats:italic>MYD88<\/jats:italic><jats:sup>L265P<\/jats:sup> (57.1%), <jats:italic>CD79B<\/jats:italic> mutation (42.9%), and <jats:italic>CDKN2A<\/jats:italic>\/<jats:italic>B<\/jats:italic> loss (71.4%) were found at high frequencies, which were similar to the mutation patterns of DLBCL of immune\u2010privileged sites compared with DLBCL NOS. DLBCL in the ileocecal area showed a characteristic mutation pattern with the most frequent <jats:italic>TP53<\/jats:italic> mutation (52.6%) and 18q21 gain (42.1%). This was also different from the mutational pattern observed in the stomach or other intestines. In discriminant analysis, DLBCL of the breast and ileocecal area tended to form separate genetic constellations from other DLBCL NOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DLBCL NOS has a characteristic mutational profile that depends on the primary organ. In particular, the mutational signature of DLBCL in the breast and ileocecal area was heterogeneous compared with that of other DLBCL NOS. Further research is needed to determine whether primary DLBCL in the breast and ileocecal area can be classified as an independent subtype.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6533","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T17:33:06Z","timestamp":1694712786000},"page":"19732-19743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Differences in mutational signature of diffuse large B\u2010cell lymphomas according to the primary organ"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2050-3564","authenticated-orcid":false,"given":"Hyun\u2010Hee","family":"Koh","sequence":"first","affiliation":[{"name":"Department of Pathology, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"},{"name":"Department of Pathology, Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Eun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-4401","authenticated-orcid":false,"given":"Seok Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Seog","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6089-9340","authenticated-orcid":false,"given":"Junhun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pathology, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015851"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012914"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802885"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0807082"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-156103"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.54343"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0016-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801445"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.03.015"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003535"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-872465"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.10.006"},{"key":"e_1_2_10_16_1","first-page":"3760","article-title":"Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B\u2010cell lymphoma reflect a GCB phenotype","volume":"5","author":"Groen RAL","year":"2021","journal-title":"Blood Adv"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000592"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3094-7"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12439"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1370546"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.622648"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-404194"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-438424"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-288480"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e318271b125"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006305"},{"key":"e_1_2_10_28_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Revised 4th Ed","author":"Swerdlow SH","year":"2017"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.584095"},{"key":"e_1_2_10_30_1","unstructured":"IGSR: The International Genome Sample Resource. In.https:\/\/www.internationalgenome.org\/"},{"key":"e_1_2_10_31_1","unstructured":"gnomAD. In.https:\/\/gnomad.broadinstitute.org\/"},{"key":"e_1_2_10_32_1","unstructured":"NHLBI Grand Opportunity Exome Seqeuncing Project (ESP). In.https:\/\/esp.gs.washington.edu\/"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baaa030"},{"key":"e_1_2_10_34_1","unstructured":"KOVA. In.https:\/\/www.kobic.re.kr\/kova\/"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.348"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-673236"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002067"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.221"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.214122"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T06:37:48Z","timestamp":1718692668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,14]]},"references-count":38,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/cam4.6533"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6533","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,14]]},"assertion":[{"value":"2023-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}