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Pulmonary lymphangitis carcinomatosis (PLC) is a peculiar manifestation of GC, whose management has not been thoroughly described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study analyzed patients diagnosed with MET\u2010amplified GC or GC with PLC at any time point of the disease course from 2011 to 2021 in two centers. Clinicopathological features and survival outcomes of MET\u2010amplified GC were analyzed. The clinical and molecular implications of GC with PLC were discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010eight patients with MET\u2010amplified GC and 20 patients with GC accompanied by PLC were finally enrolled for analysis (including 13 overlapped patients). GC with PLC was more common in female patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.010), diagnosed at a younger age (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), presented with a higher baseline ECOG PS (<jats:italic>p<\/jats:italic>\u2009=\u20090.016), and was more likely to develop lung metastasis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and serous effusion (<jats:italic>p<\/jats:italic>\u2009=\u20090.026) than GC without PLC. Patients with primary MET\u2010amplified GC had a worse prognosis than those with secondary MET\u2010amplified GC (<jats:italic>p<\/jats:italic>\u2009=\u20090.005). The application of anti\u2010MET therapy was associated with numerically prolonged survival, but the association was not statistically significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.07). MET amplification was concentrated in patients with PLC, in which anti\u2010MET therapies elicited a high response rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MET\u2010targeted therapies are efficacious in real\u2010world populations with MET\u2010amplified GC. Patients with PLC have distinct clinical and molecular features and might benefit from MET\u2010targeted therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6575","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:50:28Z","timestamp":1695981028000},"page":"19583-19594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pulmonary lymphangitis carcinomatosis: A peculiar presentation clustering in <scp>MET<\/scp>\u2010amplified gastric cancer"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8006-524X","authenticated-orcid":false,"given":"Zhening","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyi","family":"Yu","sequence":"additional","affiliation":[{"name":"Fudan Zhongshan Cancer Center Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changsong","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotian","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_12_2_1","DOI":"10.3322\/caac.21492"},{"doi-asserted-by":"publisher","key":"e_1_2_12_3_1","DOI":"10.1016\/S0140-6736(10)61121-X"},{"doi-asserted-by":"publisher","key":"e_1_2_12_4_1","DOI":"10.1158\/1078-0432.CCR-12-3898"},{"doi-asserted-by":"publisher","key":"e_1_2_12_5_1","DOI":"10.1038\/bjc.2011.603"},{"doi-asserted-by":"publisher","key":"e_1_2_12_6_1","DOI":"10.1016\/j.biopha.2018.04.178"},{"doi-asserted-by":"publisher","key":"e_1_2_12_7_1","DOI":"10.1186\/s13045-021-01034-0"},{"doi-asserted-by":"publisher","key":"e_1_2_12_8_1","DOI":"10.1016\/S1470-2045(14)70420-6"},{"doi-asserted-by":"publisher","key":"e_1_2_12_9_1","DOI":"10.1007\/s10120-015-0545-5"},{"doi-asserted-by":"publisher","key":"e_1_2_12_10_1","DOI":"10.1038\/nrc3205"},{"doi-asserted-by":"publisher","key":"e_1_2_12_11_1","DOI":"10.1038\/nrm3012"},{"doi-asserted-by":"publisher","key":"e_1_2_12_12_1","DOI":"10.1158\/1535-7163.MCT-15-0108"},{"doi-asserted-by":"publisher","key":"e_1_2_12_13_1","DOI":"10.1038\/nature13480"},{"doi-asserted-by":"publisher","key":"e_1_2_12_14_1","DOI":"10.1158\/1055-9965.EPI-10-1080"},{"doi-asserted-by":"publisher","key":"e_1_2_12_15_1","DOI":"10.1080\/10408363.2019.1653821"},{"doi-asserted-by":"publisher","key":"e_1_2_12_16_1","DOI":"10.1136\/gutjnl-2011-301839"},{"doi-asserted-by":"publisher","key":"e_1_2_12_17_1","DOI":"10.1038\/s41571-020-0377-z"},{"doi-asserted-by":"publisher","key":"e_1_2_12_18_1","DOI":"10.1001\/jamaoncol.2016.5580"},{"doi-asserted-by":"publisher","key":"e_1_2_12_19_1","DOI":"10.1016\/S1470-2045(17)30566-1"},{"doi-asserted-by":"publisher","key":"e_1_2_12_20_1","DOI":"10.1016\/j.ejca.2019.04.020"},{"doi-asserted-by":"publisher","key":"e_1_2_12_21_1","DOI":"10.1200\/JCO.2011.35.4928"},{"doi-asserted-by":"publisher","key":"e_1_2_12_22_1","DOI":"10.1158\/1078-0432.CCR-18-1337"},{"doi-asserted-by":"publisher","key":"e_1_2_12_23_1","DOI":"10.1158\/2159-8290.CD-19-0442"},{"doi-asserted-by":"publisher","key":"e_1_2_12_24_1","DOI":"10.1007\/s11523-021-00811-8"},{"doi-asserted-by":"publisher","key":"e_1_2_12_25_1","DOI":"10.1080\/00325481.2019.1595982"},{"doi-asserted-by":"publisher","key":"e_1_2_12_26_1","DOI":"10.1007\/s10637-013-0057-2"},{"doi-asserted-by":"publisher","key":"e_1_2_12_27_1","DOI":"10.1371\/journal.pone.0054014"},{"doi-asserted-by":"publisher","key":"e_1_2_12_28_1","DOI":"10.21147\/j.issn.1000-9604.2019.04.06"},{"doi-asserted-by":"publisher","key":"e_1_2_12_29_1","DOI":"10.1186\/1756-0500-5-638"},{"doi-asserted-by":"publisher","key":"e_1_2_12_30_1","DOI":"10.21037\/jgo.2018.07.06"},{"doi-asserted-by":"publisher","key":"e_1_2_12_31_1","DOI":"10.1016\/j.ejca.2018.09.024"},{"doi-asserted-by":"publisher","key":"e_1_2_12_32_1","DOI":"10.1158\/2159-8290.CD-18-0598"},{"doi-asserted-by":"publisher","key":"e_1_2_12_33_1","DOI":"10.3389\/fonc.2021.633410"},{"doi-asserted-by":"publisher","key":"e_1_2_12_34_1","DOI":"10.1038\/s41379-020-0636-7"},{"doi-asserted-by":"publisher","key":"e_1_2_12_35_1","DOI":"10.1158\/2159-8290.CD-15-0748"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T06:37:24Z","timestamp":1718692644000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":34,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/cam4.6575"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6575","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"type":"print","value":"2045-7634"},{"type":"electronic","value":"2045-7634"}],"subject":[],"published":{"date-parts":[[2023,9,29]]},"assertion":[{"value":"2023-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}