{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:40:43Z","timestamp":1782772843123,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Worldwide, gastric cancer is a leading cause of cancer incidence and mortality. This study aims to devise and validate a scoring system based on readily available clinical data to predict the risk of gastric cancer in a large Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included a total of 6,209,697 subjects aged between 18 and 70\u2009years who have received upper digestive endoscopy in Hong Kong from 1997 to 2018. A binary logistic regression model was constructed to examine the predictors of gastric cancer in a derivation cohort (<jats:italic>n<\/jats:italic>\u2009=\u20094,347,224), followed by model evaluation in a validation cohort (<jats:italic>n<\/jats:italic>\u2009=\u20091,862,473). The algorithm's discriminatory ability was evaluated as the area under the curve (AUC) of the mathematically constructed receiver operating characteristic (ROC) curve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age, male gender, history of <jats:italic>Helicobacter pylori<\/jats:italic> infection, use of proton pump inhibitors, non\u2010use of aspirin, non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs), and statins were significantly associated with gastric cancer. A scoring of \u22648 was designated as \u201caverage risk (AR)\u201d. Scores at 9 or above were assigned as \u201chigh risk (HR)\u201d. The prevalence of gastric cancer was 1.81% and 0.096%, respectively, for the HR and LR groups. The AUC for the risk score in the validation cohort was 0.834, implying an excellent fit of the model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study has validated a simple, accurate, and easy\u2010to\u2010use scoring algorithm which has a high discriminatory capability to predict gastric cancer. The score could be adopted to risk stratify subjects suspected as having gastric cancer, thus allowing prioritized upper digestive tract investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6629","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T09:54:41Z","timestamp":1697709281000},"page":"20544-20553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prediction algorithm for gastric cancer in a general population: A validation study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7706-9370","authenticated-orcid":false,"given":"Martin C. S.","family":"Wong","sequence":"first","affiliation":[{"name":"The Jockey Club School of Public Health and Primary Care, Faculty of Medicine Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Centre for Health Education and Health Promotion, Faculty of Medicine Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"School of Public Health The Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"School of Public Health The Peking University  Beijing China"},{"name":"School of Public Health Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-1785","authenticated-orcid":false,"given":"Eman Yee\u2010man","family":"Leung","sequence":"additional","affiliation":[{"name":"The Jockey Club School of Public Health and Primary Care, Faculty of Medicine Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah T. Y.","family":"Yau","sequence":"additional","affiliation":[{"name":"The Jockey Club School of Public Health and Primary Care, Faculty of Medicine Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-0569","authenticated-orcid":false,"given":"Sze Chai","family":"Chan","sequence":"additional","affiliation":[{"name":"The Jockey Club School of Public Health and Primary Care, Faculty of Medicine Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0864-8154","authenticated-orcid":false,"given":"Shaohua","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Molecular medicine and Surgery Karolinska Institutet  Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-2218","authenticated-orcid":false,"given":"Wanghong","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-4443","authenticated-orcid":false,"given":"Junjie","family":"Huang","sequence":"additional","affiliation":[{"name":"The Jockey Club School of Public Health and Primary Care, Faculty of Medicine Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Centre for Health Education and Health Promotion, Faculty of Medicine Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","unstructured":"U.S. Department of Health and Human Services NIoH. 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