{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T19:18:52Z","timestamp":1787339932168,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T00:00:00Z","timestamp":1458259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Abstract<\/jats:title>The aim of this study was to evaluate the presence of clinically and mammographically occult disease using breast MRI<\/jats:styled-content> in a cohort of cancer patients undergoing contralateral prophylactic mastectomy (CPM<\/jats:styled-content>) and the utmost indication of axillary assessment (sentinel node biopsy (SLNB<\/jats:styled-content>)) for this side. A retrospective review of patients with unilateral invasive breast cancer or ductal carcinoma in situ (DCIS<\/jats:styled-content>) from institutional MRI<\/jats:styled-content> registry data (2004\u20132010) was conducted. Characteristics of patients undergoing CPM<\/jats:styled-content> with breast MRI<\/jats:styled-content> obtained less than 6\u00a0month before surgery were evaluated. A total of 2322 consecutive patients diagnosed with DCIS<\/jats:styled-content> or stage I to III<\/jats:styled-content> infiltrating breast cancer underwent preoperative breast MRI<\/jats:styled-content>. Of these, 1376 patients (59.2%) had contralateral clinical breast exam and mammography without abnormalities; and 116 patients (4.9%) underwent CPM<\/jats:styled-content> (28 excluded patients had breast MRI<\/jats:styled-content> more than 6\u00a0months before CPM<\/jats:styled-content>). The mean age of the 88 patients was 49\u00a0years (range 28\u201376\u00a0years). Two (2.3%) DCIS<\/jats:styled-content> identified on surgical pathology specimen were not depicted by MRI<\/jats:styled-content> and the 5\u00a0mm T1N0 invasive cancer (1.1%) was identified on MRI<\/jats:styled-content>. Preoperative MRI<\/jats:styled-content> showed 95% accuracy to demonstrate absence of occult disease with negative predicted value (NPV<\/jats:styled-content>) of 98% (95% CI<\/jats:styled-content>: 91.64\u201399.64%). Occult disease was present in 3.4% of CPM<\/jats:styled-content>. MRI<\/jats:styled-content> accurately identified the case of invasive cancer in this cohort. The high negative predictive value suggests that MRI<\/jats:styled-content> can be used to select patients without consideration of SLNB for the contralateral side.<\/jats:p>","DOI":"10.1002\/cam4.663","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T09:35:39Z","timestamp":1458380139000},"page":"1031-1036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The value of breast MRI<\/scp> in high\u2010risk patients with newly diagnosed breast cancer to exclude invasive disease in the contralateral prophylactic mastectomy: Is there a role to choose wisely patients for sentinel node biopsy?"],"prefix":"10.1002","volume":"5","author":[{"given":"Vivianne","family":"Freitas","sequence":"first","affiliation":[{"name":"Department of Medical Imaging Mount Sinai Hospital and University Health Network University of Toronto Toronto Ontario 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