{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:54:50Z","timestamp":1791298490944,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Similar to many countries, Belgium experienced a rapid increase in cancer diagnoses in the last years. Considering that a large part of cancer types could be prevented, our study aimed to estimate the annual healthcare burden of cancer per site, and to compare cost with burden of disease estimates to have a better understanding of the impact of different cancer sites in Belgium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used nationally available data sources to estimate the healthcare expenditure. We opted for a prevalence\u2010based approach which measures the disease attributable costs that occur concurrently for 10\u2010year prevalent cancer cases in 2018. Average attributable costs of cancer were computed via matching of cases (patients with cancer by site) and controls (patients without cancer). Years of life lost due to disability (YLD) were used to summarize the health impact of the selected cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The highest attributable cost in 2018 among the selected cancers was on average \u20ac15,867 per patient for bronchus and lung cancer, followed by liver cancer, pancreatic cancer, and mesothelioma. For the total cost, lung cancer was the most costly cancer site with almost \u20ac700 million spent in 2018. Lung cancer was followed by breast and colorectal cancer that costed more than \u20ac300 million each in 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our study, the direct attributable cost of the most prevalent cancer sites in Belgium was estimated to provide useful guidance for cost containment policies. Many of these cancers could be prevented by tackling risk factors such as smoking, obesity, and environmental stressors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6659","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T02:09:48Z","timestamp":1706148588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The incremental healthcare cost associated with cancer in Belgium: A registry\u2010based data analysis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6884-9316","authenticated-orcid":false,"given":"Vanessa","family":"Gorasso","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Public Health Sciensano  Brussels Belgium"},{"name":"Department of Public Health and Primary Care Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Vandevijvere","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Sciensano  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Van\u00a0der\u00a0Heyden","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Sciensano  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Pelgrims","sequence":"additional","affiliation":[{"name":"Department of Risk and Health Impact Assessment Sciensano  Brussels Belgium"},{"name":"Department of Applied Mathematics, Computer Science and Statistics Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk","family":"Hilderink","sequence":"additional","affiliation":[{"name":"Centre for Public Health Forecasting National Institute for Public Health and the Environment (RIVM)  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma","family":"Nusselder","sequence":"additional","affiliation":[{"name":"Department of Public Health Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Demoury","sequence":"additional","affiliation":[{"name":"Department of Risk and Health Impact Assessment Sciensano  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masja","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Sciensano  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn","family":"Vansteelandt","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics, Computer Science and Statistics Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"De\u00a0Smedt","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brecht","family":"Devleesschauwer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Sciensano  Brussels Belgium"},{"name":"Department of Translational Physiology Infectiology and Public Health, Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-09109-4"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241354"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.01.011"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2005.07.016"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.34.15_suppl.6618"},{"key":"e_1_2_12_7_1","volume-title":"The Impact of Skin Cancer in Belgium and the Cost\u2010Effectiveness of Prevention","author":"Pil L","year":"2016"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-010-0237-3"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/11588380-000000000-00000"},{"key":"e_1_2_12_10_1","unstructured":"Belgian Cancer Registry.Cancer Burden in Belgium 2004\u20132017.2020[Online].https:\/\/kankerregister.org\/media\/docs\/CancerBurdenfeb2020reduced.pdf"},{"key":"e_1_2_12_11_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1214\/13-STS453"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq472"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00147-3"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-1534"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2014.20.4.327"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv215"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr301"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T02:07:27Z","timestamp":1712628447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,24]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/cam4.6659"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6659","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3142514\/v1","asserted-by":"object"}]},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,24]]},"assertion":[{"value":"2023-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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