{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:22:13Z","timestamp":1769840533988,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study analyzed the impact of the coronavirus disease 2019 (COVID\u201019) pandemic on radiotherapy delivery in Japan using a high\u2010quality Japanese national database based on universal health coverage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective observational study using National Database of Health Insurance Claims and Specific Health Checkups of Japan open data focused on radiotherapy between fiscal year (FY) 2019 and FY2020 and the number of COVID\u201019 cases from the Ministry of Health, Labour, and Welfare. We statistically analyzed the relationship between the number of COVID\u201019 cases and the number of radiotherapy deliveries in Japan as a whole and by prefecture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total number of external beam radiotherapy (EBRT) fractions was 4,472,140 in FY2019 and 4,227,673 in FY2020 (\u22125.8%). EBRT courses were 250,395 in FY2019 and 240,329 in FY2020 (\u22124.0%), stereotactic radiotherapy courses were 27,619 in FY2019 and 31,786 in FY2020 (+15.1%), and single\u2010fraction palliative radiotherapy courses were 4124 in FY2019 and 5255 in FY2020 (+21.5%). The total number of breast and prostate hypofractionated radiotherapy (HFRT) fractions was 155,773 and 48,188 in FY2019, and 200,256 and 84,230 in FY2020 (+28.6% and +74.8%), respectively. In the Pearson correlation analysis, EBRT fractions were lower, and breast HFRT fractions were higher in prefectures with more COVID\u201019 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, radiotherapy delivery in Japan was relatively stable after the pandemic, with an increase in HFRT. Also, EBRT fractions decreased, and breast HFRT were more likely to be used in prefectures with more COVID\u201019 cases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6661","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T12:09:14Z","timestamp":1698667754000},"page":"21032-21040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The impact of the <scp>COVID<\/scp>\u201019 pandemic on radiotherapy delivery in Japan: An observational study based on the national database"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2290-1905","authenticated-orcid":false,"given":"Keisuke","family":"Tamari","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko","family":"Kishigami","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8135-8746","authenticated-orcid":false,"given":"Takashi","family":"Mizowaki","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Image\u2010Applied Therapy, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kodaira","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Aichi Cancer Center Hospital  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Yamanashi School of Medicine  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Shioyama","sequence":"additional","affiliation":[{"name":"Ion Beam Therapy Center SAGA\u2010HIMAT Foundation  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Shigematsu","sequence":"additional","affiliation":[{"name":"Department of Radiology Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Uno","sequence":"additional","affiliation":[{"name":"Department of Radiology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01381-y"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01750-1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/GO.20.00639"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.05.042"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrac055"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.06.007"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.01.045"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60828-3"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.37737\/ace.2.1_13"},{"key":"e_1_2_12_11_1","unstructured":"Ministry of Health L and W.6th NDB Open Data. 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