{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:39:10Z","timestamp":1747147150436,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872902","82073917","82103579","82104273"],"award-info":[{"award-number":["81872902","82073917","82103579","82104273"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2018ZX09734003"],"award-info":[{"award-number":["2018ZX09734003"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This real\u2010world study investigated the outcome of COVID\u201019 in lymphoma patients participating in registered clinical trials and explored potential risk factors with the outcome of COVID\u201019 during the first wave of the Omicron outbreak in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and ten patients participating in registered clinical trials and diagnosed with COVID\u201019 in our center between December 1, 2022, and January 31, 2023, were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four (3.6%) patients were identified as severe COVID\u201019 and 2 (1.8%) as critical COVID\u201019, respectively. The mortality rate observed was 2.73% for the entire cohort, 33.3% for the severe\/critical COVID\u201019 group, and 18.8% for the hospitalized group. The 90\u2010day OS was 98.2% for the entire cohort, 66.7% for the severe\/critical COVID\u201019 group, and 87.5% for the hospitalized group. Advanced age (\u226570\u2009years), comorbidities, and PI3K inhibitor\u2010containing regimen were significantly associated with the severity of COVID\u201019. Patients with indolent B\u2010cell non\u2010Hodgkin lymphomas were less likely to be hospitalized for COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study reported similar clinical features of COVID\u201019 in our cohort with that of non\u2010hematological malignancy (HM) patients, while the proportion of severe\/critical COVID\u201019 and the mortality rate were relatively higher than non\u2010HM patients. Our findings provided valuable experience to aid clinical researchers with managing lymphoma patients participating in registered clinical trials during the ongoing pandemic of the Omicron variant.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6678","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T01:26:11Z","timestamp":1701134771000},"page":"21148-21158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes of <scp>COVID<\/scp>\u201019 in patients with lymphomas participating in registered clinical trials: A real\u2010world study from China in the Omicron outbreak era"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3811-0371","authenticated-orcid":false,"given":"Peng","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010Sen University Cancer Center  Guangzhou China"},{"name":"State Key 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