{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:42:11Z","timestamp":1773243731285,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1411400"],"award-info":[{"award-number":["22ZR1411400"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity is a risk factor for multiple myeloma (MM). However, we still lack knowledge on the clinical course of obese MM patients in a broad view.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we reviewed 568\u2009MM patients recorded in the Multiple Myeloma Research Foundation (MMRF) coMMpass dataset. Patients were divided into the normal and obese groups according body mass index (BMI) at diagnosis, and then the baseline characteristics, cytogenetic abnormalities, treatment variability, and survival outcomes were evaluated in the obese cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found no differences in the characteristics when comparing normal and obese MM patients other than more male in the obese part (50.4% vs. 59.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.024). Compared with the normal BMI patients, median overall survival (OS) was shorter for obese MM patients but without significant meaning (82.3 vs. 95.3\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.25). However, in the subgroup analysis, obese MM patients younger than 65\u2009years had significantly inferior OS than that in the normal category (<jats:italic>p<\/jats:italic>\u2009=\u20090.047). We also found obese MM patients had a higher overall response rate (ORR) compared with normal BMI patients (92.7% vs. 88.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.037). Additionally, obese patients seemed to achieve faster best response during first\u2010line therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Obesity assumes a paradoxical function in the clinical trajectory of myeloma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6685","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T13:27:15Z","timestamp":1699277235000},"page":"21400-21407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The obesity paradox in multiple myeloma: A report from Multiple Myeloma Research Foundation (MMRF) dataset"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0678-0987","authenticated-orcid":false,"given":"Liang","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Hematology Zhongshan Hospital, Fudan University  Shanghai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhongshan Hospital, Fudan University  Shanghai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhongshan Hospital, Fudan University  Shanghai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-6606","authenticated-orcid":false,"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhongshan Hospital, Fudan University  Shanghai P. R. China"},{"name":"Cancer Center Zhongshan Hospital, Fudan University  Shanghai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.313"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008926027805"},{"issue":"2","key":"e_1_2_9_5_1","first-page":"323","article-title":"Multiple myeloma among atomic bomb survivors in Hiroshima and Nagasaki, 1950\u201076: relationship to radiation dose absorbed by marrow","volume":"69","author":"Ichimaru M","year":"1982","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2307\/3578893"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.11.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.4837"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0206"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-016-0674-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.2128"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404658"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-1088"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.01.020"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39367.495995.AE"},{"issue":"9","key":"e_1_2_9_17_1","first-page":"706","article-title":"Influence of obesity on drug disposition","volume":"6","author":"Blouin RA","year":"1987","journal-title":"Clin Pharm"},{"key":"e_1_2_9_18_1","first-page":"i","article-title":"Obesity: preventing and managing the global epidemic. 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