{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:18:37Z","timestamp":1791357517192,"version":"4.3.1"},"reference-count":35,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backgroud<\/jats:title>\n                    <jats:p>Multiple studies have identified pathogenic germline variants in cancer susceptibility genes (CSGs) in Chinese lung cancer patients; however, accurate assessment of these variants' contributions to cancer predisposition is always hampered by the absence of data on the prevalence of these variants in the general population. It is necessary to conduct a large\u2010scale case\u2013control study to identify CSGs that significantly increase the risk of lung cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We performed targeted sequencing of a CSGs panel in 1117 lung cancer patients and 16,327 controls from the general Chinese population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In comparison to controls, lung cancer patients had a considerably higher prevalence of pathogenic and likely pathogenic (P\/LP) variations. Among lung cancer patients, 72% of P\/LP variants carriers did not have a family cancer history, who would be ignored if germline testing was only provided for patients meeting family history\u2010based criteria. Furthermore, compared to individuals with late\u2010onset lung cancer, patients with early\u2010onset lung cancer had a considerably higher prevalence of P\/LP variations. With odds ratios (ORs) ranging from 4\u2010fold (\n                      <jats:italic>BRCA1<\/jats:italic>\n                      : OR, 4.193; 95%CI, 1.382\u201310.768) to 29\u2010fold (\n                      <jats:italic>TP53<\/jats:italic>\n                      : OR, 29.281; 95%CI, 1.523\u20131705.506), P\/LP variants in the\n                      <jats:italic>BRCA1<\/jats:italic>\n                      and\n                      <jats:italic>TP53<\/jats:italic>\n                      genes were discovered to be strongly related to increased lung cancer risk. Additionally, with ORs ranging from 7.322\u2010fold to infinity, we discovered 23 variations previously categorized as non\u2010P\/LP variants were highly enriched in lung cancer patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings indicated that P\/LP variants in\n                      <jats:italic>BRCA1<\/jats:italic>\n                      and\n                      <jats:italic>TP53<\/jats:italic>\n                      conferred increased risk of lung cancer in Chinese.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6692","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T09:18:31Z","timestamp":1699262311000},"page":"21219-21228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pathogenic germline variants in\n                    <scp>\n                      <i>BRCA1<\/i>\n                    <\/scp>\n                    and\n                    <scp>\n                      <i>TP53<\/i>\n                    <\/scp>\n                    increase lung cancer risk in Chinese"],"prefix":"10.1002","volume":"12","author":[{"given":"Bing","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Molecular Pathology, Henan Key Laboratory of Molecular Pathology The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan 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Shenyou Institute of Genome Research  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology, Henan Key Laboratory of Molecular Pathology The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology, Henan Key Laboratory of Molecular Pathology The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology, Henan Key Laboratory of Molecular Pathology The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  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