{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:54:15Z","timestamp":1790409255432,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Daratumumab is a humanized monoclonal antibody approved for the treatment of adult patients with newly diagnosed or relapsed\/refractory multiple myeloma (RRMM). Subcutaneous (SC) formulation proved to be non\u2010inferior in comparison with intravenous (IV) administration route. This study aimed at assessing the economic and time impact associated with the use of SC versus IV daratumumab in patients with RRMM from the perspective of the hematology center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a 5\u2010month multicenter time\u2010and\u2010motion cross\u2010sectional micro\u2010costing study conducted in three Italian hematology centers among adult patients diagnosed with RRMM with ongoing treatment with IV or SC daratumumab. Measurements were performed by an ad hoc App.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen (20%) IV and 76 (80%) SC administration procedures were measured. Patients spent a mean of 4.85\u2009\u00b1\u20090.91 or 1.08\u2009\u00b1\u20090.56\u2009h in the hematology center to receive IV or SC daratumumab, respectively. Healthcare professionals (HCPs) spent a mean of 49.38\u2009\u00b1\u200916.13 and 20.37\u2009\u00b1\u20097.88\u2009min of active working time to manage IV and SC administrations, respectively. The infusion chair was occupied for a mean of 4.85\u2009\u00b1\u20090.91 and 0.99\u2009\u00b1\u20090.55\u2009h during IV or SC administration, respectively. On average, considering the costs due to HCP and chair time, materials, and overhead costs, every IV and SC administration costed \u20ac80.33 and 34.90, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, as compared with IV administration, SC daratumumab was associated with 78%, 59%, 80% savings in terms of patient time, HCP active working time, and infusion chair, respectively, and 56.6% budget savings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6699","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T09:49:25Z","timestamp":1699523365000},"page":"21480-21489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Improved efficiency of daratumumab treatment of multiple myeloma adopting the subcutaneous route: A micro\u2010costing analysis in three Italian hematology centers"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7648-8917","authenticated-orcid":false,"given":"Lorenzo","family":"Pradelli","sequence":"first","affiliation":[{"name":"AdRes HE&amp;OR  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Massaia","sequence":"additional","affiliation":[{"name":"S.C. 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