{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:07:59Z","timestamp":1785510479698,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515111119"],"award-info":[{"award-number":["2022A1515111119"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There is no consensus regarding the best interval time between transurethral resection of a bladder tumor and Bacillus Calmette\u2010Guerin (BCG) perfusion. This study was to explore whether the interval time has an impact on the prognosis and adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the clinical data of patients who received BCG intravesical perfusion at Sun Yat\u2010sen University Cancer Center (SYSUCC) from September 2015 to October 2021. Recurrence\u2010free survival (RFS) and progression\u2010free survival were the primary endpoints. Cox regression was used to explore independent predictors. The association between interval time and adverse effect grade was detected by logistic regression. Propensity score matching (PSM) was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 403 patients were enrolled, the median interval time was 24\u2009days (6\u2013163\u2009days), and the follow\u2010up was 28\u2009months (7\u201382\u2009months). Eighty\u2010eight (20.9%) patients relapsed, and 40 patients (10.0%) suffered progression. The multivariate Cox regression analysis confirmed that interval time was an independent predictor of RFS (<jats:italic>p<\/jats:italic>\u2009=\u20090.017). Notably, when the interval time was less than or equal to 26\u2009days, there was a trend toward better RFS, PSM resulted in 65 matched pairs in each group, and Kaplan\u2013Meier analysis showed that there was a significant difference in RFS between groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.009). The logistic regression analysis showed that there was no correlation between interval time and adverse effects and their grades (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We considered that the first BCG perfusion could be performed within 2\u20134\u2009weeks after surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6707","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T12:46:08Z","timestamp":1699965968000},"page":"21279-21286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Optimal interval timing between transurethral resection of bladder tumors and Bacillus <scp>Calmette\u2010Guerin<\/scp> perfusion"],"prefix":"10.1002","volume":"12","author":[{"given":"Tao\u2010nong","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang\u2010li","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery II Zhujiang Hospital of Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-3033","authenticated-orcid":false,"given":"Zhuo\u2010wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010ke","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5424-7066","authenticated-orcid":false,"given":"Yun\u2010lin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20194192"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.05.027"},{"key":"e_1_2_12_5_1","first-page":"1","article-title":"EAU guidelines on non\u2010muscle\u2010invasive bladder cancer (TaT1 and CIS)","volume":"2023","author":"Gontero P","year":"2023","journal-title":"Eur Urol"},{"key":"e_1_2_12_6_1","unstructured":"ThomasW FlaigM PhilippeE SpiessM Michael AbernM et\u00a0al.Bladder cancer (version 3.2023) NCCN clinical practice guidelines in oncology (NCCN Guidelines\u00ae).2023. 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