{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:17:48Z","timestamp":1775841468379,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Immune\u2010related pneumonitis is a rare and potentially fatal adverse event associated with sintilimab. We aimed to develop and validate a nomogram for predicting the risk of immune\u2010related pneumonitis in patients treated with sintilimab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The least absolute shrinkage and selection operator (LASSO) regression was used to determine risk factors. Multivariable logistic regression was used to establish a prediction model. Its clinical validity was evaluated using calibration, discrimination, decision, and clinical impact curves. Internal validation was performed against the validation set and complete dataset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 632 patients; 59 were diagnosed with immune\u2010related pneumonitis. LASSO regression analysis identified that the risk factors for immune\u2010related pneumonitis were pulmonary metastases (odds ratio [OR], 4.015; 95% confidence interval [CI]: 1.725\u20139.340) and metastases at &gt;3 sites (OR, 2.687; 95% CI: 1.151\u20136.269). The use of combined antibiotics (OR, 0.247; 95% CI: 0.083\u20130.738) and proton pump inhibitors (OR, 0.420; 95% CI: 0.211\u20130.837) were protective factors. The decision and clinical impact curves showed that the nomogram had clinical value for patients treated with sintilimab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have developed and validated a practical nomogram model of sintilimab\u2010associated immune\u2010related pneumonitis, which provides clinical value for determining the risk of immune\u2010related pneumonitis and facilitating the safe administration of sintilimab therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6708","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T09:20:03Z","timestamp":1705051203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Development and validation of a nomogram for predicting immune\u2010related pneumonitis after sintilimab treatment"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2185-9095","authenticated-orcid":false,"given":"Baohui","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Second Hospital of Sanming City  Sanming China"},{"name":"Department of Pharmacy Fujian Medical University Union Hospital  Fuzhou China"},{"name":"The School of Pharmacy Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Second Hospital of Sanming City  Sanming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caiyun","family":"Zheng","sequence":"additional","affiliation":[{"name":"The School of Pharmacy Fujian Medical University  Fuzhou China"},{"name":"Fuqing City Hospital Affiliated to Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maobai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Fujian Medical University Union Hospital  Fuzhou China"},{"name":"The School of Pharmacy Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Fujian Medical University Union Hospital  Fuzhou China"},{"name":"The School of Pharmacy Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-1066-z"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0578-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.0012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0805-8"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.07.014"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.04.011"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-068714"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.09.015"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.08.2035"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2019.07.006"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.570233"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1579"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2022.06.001"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-22-72"},{"key":"e_1_2_11_16_1","unstructured":"National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE). v.4.0; 2009. Accessed March 3 2009.https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/ctc.htm"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1320"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0218-0"},{"key":"e_1_2_11_19_1","volume-title":"The Elements of Statistical Learning: Data Mining, Inference, and Prediction","author":"Hastie T","year":"2008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3462-1"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132438"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0698"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1760"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0066-7"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18701-4"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09642-w"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.06.021"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.08.036"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-57"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i22.2706"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310861"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-6427"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13329"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T06:13:37Z","timestamp":1712643217000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,12]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/cam4.6708"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6708","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,12]]},"assertion":[{"value":"2023-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6708"}}