{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:55:35Z","timestamp":1769061335656,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Glioblastoma (GBM) is a tumor with rapid growth and a possible relationship to elevated intracranial pressure (ICP). High ICP may not always be associated with clinical signs. A non\u2010invasive technique for assessment of ICP is measuring the optic nerve sheath diameter (ONSD). Identifying patients who need immediate intervention is of importance in neuro\u2010oncological care. The goal of this study is to assess the available magnetic resonance imaging (MRI) of patients with GBM with respect to pre\u2010 and postoperative ONSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>Retrospective data analysis was performed on all patients operated for GBM at a tertiary care center between 2010 and 2020. Two pre and one postoperative MRI had to be available. Clinical data and ONSD at multiple time points were analyzed and correlated, as well as preoperative volumetrics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010seven patients met the inclusion criteria. Clinical signs of elevated ICP were seen in 25.4% (<jats:italic>n<\/jats:italic>\u2009=\u200917), while significant perifocal edema was present in 67.2% (<jats:italic>n<\/jats:italic>\u2009=\u200945) of patients. Clinical signs of preoperatively elevated ICP were associated with significantly elevated ONSD at diagnosis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) as well as preoperative tumor volume (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Significant perifocal edema at the time of diagnosis was associated with elevated ONSD (<jats:italic>p<\/jats:italic>\u2009=\u20090.029) and higher tumor volume (<jats:italic>p<\/jats:italic>\u2009=\u20090.003). In patients with significant edema, ONSD increased significantly between preoperative MRIs (<jats:italic>p<\/jats:italic>\u2009=\u20090.003\/005). In patients with clinical signs of raised ICP, ONSD also increased, whereas it was stable in asymptomatic patients (yes: 5.01+\/\u22124.17 to 5.83+\/\u22120.55\u2009mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.010, no: 5.17+\/\u22120.46\u2009mm to 5.38+\/\u22120.41\u2009mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.81). A significant increase of ONSD from diagnosis to preoperative MRI and a significant decrease until 3\u2009months postoperatively were observed (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ONSD might help identify high ICP in patients with GBM. In this first\u2010of\u2010its kind study, we observed a significant increase of ONSD preoperatively, likely associated with edema. Postoperatively, ONSD decreased significantly until 3\u2009months after surgery and increased again at 12\u2009months. Further prospective data collection is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6789","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T15:51:31Z","timestamp":1702050691000},"page":"22047-22055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Retrospective longitudinal assessment of optic nerve sheath diameter in patients with malignant glioma"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3674-1698","authenticated-orcid":false,"given":"Daniel","family":"Feucht","sequence":"first","affiliation":[{"name":"Department of Neurosurgery University Hospital of Tuebingen  Tubingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne R.","family":"Kerscher","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Ruff","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology University Hospital of Tuebingen  Tubingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin U.","family":"Schuhmann","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospital of Tuebingen  Tubingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin","family":"Roder","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospital of Tuebingen  Tubingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Zipfel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospital of Tuebingen  Tubingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2021.0922"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06478-x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2021.08.002"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-019-04336-4"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-019-04266-1"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.6560"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2016.09.044"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-022-05479-1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1744117"},{"issue":"1","key":"e_1_2_12_11_1","article-title":"Timing of glioblastoma surgery and patient outcomes: a multicenter cohort study","volume":"3","author":"Muller DMJ","year":"2021","journal-title":"Neurooncol Adv"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2019.02.030"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2023.5.JNS23388","article-title":"Does waiting for surgery matter? How time from diagnostic MRI to resection affects outcomes in newly diagnosed glioblastoma","author":"Young JS","year":"2023","journal-title":"J Neurosurg"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01364"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.53198"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.10.001"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000001038"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5484"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-016-3067-5"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02159.x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/01658107.2016.1226344"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2017.70"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-300663"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00764"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2018.14.3.345"},{"issue":"10","key":"e_1_2_12_26_1","first-page":"884","article-title":"Pseudotumor cerebri: quantitative in\u2010vivo measurements of markers of intracranial hypertension","volume":"180","author":"Rohr A","year":"2008","journal-title":"Rofo"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-187"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12764"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1245822"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T08:57:50Z","timestamp":1705222670000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":28,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/cam4.6789"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6789","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}