{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T11:15:27Z","timestamp":1742382927595,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:00:00Z","timestamp":1456704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"crossref","award":["6-2014-0133"],"award-info":[{"award-number":["6-2014-0133"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bone marrow involvement (BMI) is a well\u2010known poor prognostic factor in patients with diffuse large B\u2010cell lymphoma (DLBCL). This study robustly investigated the significance of monoclonal immunoglobulin gene rearrangement combined with histologic B\u2010cell aggregates in bone marrow (BM) in the detection of a poor prognostic group. Pretreatment BM samples of 394 DLBCL patients were analyzed via the immunoglobulin gene rearrangement study and the microscopic examination. Monoclonal immunoglobulin gene rearrangement was detected in 25.4% of cases. Histologic B\u2010cell aggregates with the features of large B\u2010cell lymphoma aggregates, small cell B\u2010cell lymphoma aggregates, or B\u2010cell aggregates of unknown biological potential were observed in 12% of cases (6.9%, 1.3%, and 3.8%, respectively). Histologic B\u2010cell aggregates were more associated with monoclonality than polyclonality. Cases with both monoclonality and histologic B\u2010cell aggregates demonstrated close association with poor prognostic factors such as a higher International Prognostic Index score and showed an inferior overall survival rate when compared to cases with only monoclonality or only histologic B\u2010cell aggregates. From the findings, a combination of monoclonality and histologic B\u2010cell aggregates within the bone marrow was highly associated with poor prognosis and could be used to determine high\u2010risk DLBLC patients with greater sensitivity and specificity than conventional microscopic examination or immunoglobulin gene rearrangement study alone.<\/jats:p>","DOI":"10.1002\/cam4.679","type":"journal-article","created":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T10:29:33Z","timestamp":1456741773000},"page":"1066-1073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The prognostic significance of monoclonal immunoglobulin gene rearrangement in conjunction with histologic B\u2010cell aggregates in the bone marrow of patients with diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"5","author":[{"given":"Yoon Ah","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Pathology Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Ick","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Woo","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo Hong","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Och","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Pathology Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,29]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"439","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow S. 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