{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:35:04Z","timestamp":1784763304040,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Peripheral T\u2010cell lymphoma not otherwise specified (PTCL\u2010NOS) is a heterogeneous disease that can be classified into the PTCL\u2010TBX21 and PTCL\u2010GATA3 subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we compared the clinicopathological features of PTCL\u2010NOS in a Japanese cohort, classified using an IHC algorithm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred patients with PTCL\u2010NOS were categorized as having PTCL\u2010TBX21 (<jats:italic>n<\/jats:italic>\u2009=\u200955), PTCL\u2010GATA3 (<jats:italic>n<\/jats:italic>\u2009=\u200924), or PTCL\u2010unclassified (<jats:italic>n<\/jats:italic>\u2009=\u200921). When comparing PTCL\u2010TBX21 and PTCL\u2010GATA3, PTCL\u2010TBX21 showed significantly lower CD4 positivity (<jats:italic>p<\/jats:italic>\u2009=\u20090.047), lower counts of high endothelial venules (<jats:italic>p<\/jats:italic>\u2009=\u20090.032), and a tendency for a better response to initial treatment (<jats:italic>p<\/jats:italic>\u2009=\u20090.088). Gene expression analysis using the nCounter system showed higher expression of tumor immunity\u2010related genes, such as PD\u2010L1, LAG3, and IDO1, in PTCL\u2010TBX21 than in PTCL\u2010GATA3. PTCL\u2010GATA3 had significantly worse overall survival (OS) than those with PTCL\u2010TBX21 (<jats:italic>p<\/jats:italic>\u2009=\u20090.047), although a similar tendency was observed for progression\u2010free survival (PFS) (<jats:italic>p<\/jats:italic>\u2009=\u20090.064). PTCL\u2010GATA3 was a prognostic factor for OS in univariate analysis (HR 2.02; 95% CI, 1.09\u20133.77; <jats:italic>p<\/jats:italic>\u2009=\u20090.027), although multivariate analysis did not show significance (HR 2.07; 95% CI, 0.93\u20134.61; <jats:italic>p<\/jats:italic>\u2009=\u20090.074). In the PFS analysis, PTCL\u2010GATA3 was an independent prognostic factor by univariate analysis (HR 1.96; 95% CI, 1.08\u20133.56; <jats:italic>p<\/jats:italic>\u2009=\u20090.027) and multivariate analysis (HR 2.34; 95% CI, 1.07\u20135.11; <jats:italic>p<\/jats:italic>\u2009=\u20090.032).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The classification of PTCL\u2010NOS into PTCL\u2010TBX21 and PTCL\u2010GATA3 is useful for predicting the prognosis of Japanese patients and stratifying the administration of tumor immune checkpoint inhibitors in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6793","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T07:56:18Z","timestamp":1705564578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinicopathological comparison between PTCL\u2010TBX21 and PTCL\u2010GATA3 in Japanese patients"],"prefix":"10.1002","volume":"13","author":[{"given":"Yasumasa","family":"Shimasaki","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Kurume Japan"},{"name":"Department of Hematology Shimane University Hospital  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-3725","authenticated-orcid":false,"given":"Hiroaki","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Kurume Japan"},{"name":"Department of Hematology, Endocrinology, and Metabolism, Faculty of Medicine Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Kurume Japan"},{"name":"Department of Clinical Studies Radiation Effects Research Foundation  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuzo","family":"Mishina","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Kurume Japan"},{"name":"Department of Hematology Chiba University Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Imamoto","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Kurume Japan"},{"name":"Department of Surgical Pathology Hokkaido University Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sugio","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeharu","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyohei","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaharu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology, and Metabolism, Faculty of Medicine Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3382-0473","authenticated-orcid":false,"given":"Mayuko","family":"Moritsubo","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-5691","authenticated-orcid":false,"given":"Yoshitaka","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology, and Metabolism, Faculty of Medicine Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Suzumiya","sequence":"additional","affiliation":[{"name":"Department of Hematology Kohga Hospital  Yaizu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Hematology Shimane University Hospital  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Peripheral T\u2010Cell Lymphoma, Not Otherwise Specified World Health Organisation Classification of Tumors of Haematopoietic and Lymphoid Tissues","author":"Pileri SA","year":"2017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh392"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.12.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.7.2348"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065543"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80240-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.11.1545"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1178"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp021"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04999.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.25"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1352"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-536359"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000779"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-12-544809"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018018754"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0473-1"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.05.002"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2152-2650(22)01084-9"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-09-872549"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.03.014"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1457"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3790"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.010"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.143"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0512-0"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T06:12:27Z","timestamp":1712643147000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,17]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/cam4.6793"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6793","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,17]]},"assertion":[{"value":"2023-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6793"}}