{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T19:35:52Z","timestamp":1770492952062,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072972"],"award-info":[{"award-number":["82072972"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Soft tissue metastasis (STM) of cancers, encompassing skeletal muscle and subcutaneous tissue metastasis, is less common due to unique homeostatic conditions. With longer life expectancy and the advent of new imaging modalities, clinical physicians will increasingly encounter and manage such cases. This study retrospectively reviewed cases of STM in visceral cancers who underwent surgery at Fudan University Shanghai Cancer Center over a 7\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected through a comprehensive review of medical records, including demographic variables, primary tumor characteristics, surgical data, tumor pathology, and outcomes. Survival analysis was performed using Kaplan\u2013Meier curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 77 cases with a median follow\u2010up period of 854\u2009days. The most common primary tumor sites were the lung (11) and breast (10). The abdominal wall was the most frequent site of metastasis. The combination of visceral metastasis, age over 52\u2009years, and a history of primary tumor correlates with a poorer prognosis. Surgical\u2010related metastases are associated with a higher degree of differentiation. Additionally, we have identified a better prognosis for patients with cancer of unknown primary (CUP) exhibiting potential resectable soft tissue metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of visceral metastasis, age over 52\u2009years, and a history of primary tumor suggest a poorer prognosis. While no significant impact on survival was observed for patients with lymph node metastasis. Surgical\u2010related metastases are associated with a higher degree of differentiation. CUP patients with potentially resectable soft tissue metastases should be considered for surgical intervention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6808","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T21:07:14Z","timestamp":1702415234000},"page":"22081-22090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Surgical resection of soft tissue metastasis in cancers: A <scp>single\u2010center<\/scp> study of 77 cases over a <scp>7\u2010year<\/scp> period"],"prefix":"10.1002","volume":"12","author":[{"given":"Qingrong","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengwang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9938-7596","authenticated-orcid":false,"given":"Peihang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangbai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wangjun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.19.00114"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23151"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.9.11.757"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"57","article-title":"Metastasis of malignant neoplasms to skeletal muscle","volume":"31","author":"Acinas Garc\u00eda O","year":"1984","journal-title":"Rev Esp Oncol"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050606"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-017-2782-z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2342-7-8"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(05)70183-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-009-1043-1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2010.11680645"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2023.107967"},{"key":"e_1_2_10_13_1","article-title":"Metastasis of the abdominal wall in a patient with diagnosis of pulmonary adenocarcinoma: an interesting finding","volume":"38","author":"Mancera J","year":"2022","journal-title":"Respir Med Case Rep"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-000-0526-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-019-04160-w"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870415)59:8<1530::AID-CNCR2820590824>3.0.CO;2-H"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0713"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(80)90079-1"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.059"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1470-7330-14-21"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-011-1319-8"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007760100070"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/819797","article-title":"Clinical significance and prognostic impact of subcutaneous or Intrastrap muscular recurrence of papillary thyroid carcinoma","volume":"2012","author":"Ito Y","year":"2012","journal-title":"J Thyroid Res"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-018-9896-8"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq199"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyh036"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.11.014"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2011.158"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27988"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr536"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1303917"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80700-4"},{"issue":"6","key":"e_1_2_10_33_1","first-page":"1068","article-title":"Incision site metastasis: adding insult to injury","volume":"13","author":"Boaz RJ","year":"2017","journal-title":"J Cancer Res Ther"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3394"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.178.4.1780985"},{"issue":"1","key":"e_1_2_10_36_1","first-page":"85","article-title":"Incidental gall bladder carcinoma in laparoscopic cholecystectomy: a report of 6 cases and a review of the literature","volume":"7","author":"Sujata J","year":"2013","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.08.007"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T08:55:01Z","timestamp":1705222501000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":36,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/cam4.6808"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6808","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}