{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:55:43Z","timestamp":1791435343838,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072564"],"award-info":[{"award-number":["82072564"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic Research Leader","doi-asserted-by":"publisher","award":["22XD142280"],"award-info":[{"award-number":["22XD142280"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2022XD029"],"award-info":[{"award-number":["2022XD029"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>SMARCA4\u2010deficient thoracic tumors, characterized by distinct clinicopathological, morphological, immunohistochemical, and genetic features, differ significantly from conventional non\u2010small\u2010cell lung carcinomas (NSCLCs). This group encompasses both SMARCA4\u2010deficient NSCLCs (SMARCA4\u2010NSCLCs) and SMARCA4\u2010deficient undifferentiated tumors (SMARCA4\u2010UTs). The efficacy of PD\u20101 inhibitors in treating SMARCA4\u2010deficient thoracic tumors remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of 36 patients diagnosed with stage IIIB, IIIC, or IV SMARCA4\u2010deficient thoracic tumors were analyzed. We assessed the clinical, pathological, and genetic features of these patients through immunohistochemistry (IHC) and a 68\u2010gene panel next\u2010generation sequencing (NGS). We compared the differences between SMARCA4\u2010NSCLCs and SMARCA4\u2010UTs, and evaluated the impact of chemotherapy and immunotherapy on patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of patients with SMARCA4\u2010deficient thoracic tumors were heavy\u2010smoking males, averaging 64.6\u2009years in age. IHC predominantly showed weak or negative staining for markers such as TTF\u20101, CK5\/6, p40, synaptophysin, chromogranin A, and CD56, which are often associated with adenocarcinoma, squamous cell carcinoma, and neuroendocrine tumors. The most common genetic mutations identified via NGS included TP53, CDKN2A, KRAS, STK11, NF1, and PTEN. No significant overall survival (OS) difference was observed between SMARCA4\u2010NSCLCs and SMARCA4\u2010UTs (<jats:italic>p<\/jats:italic>\u2009=\u20090.366). The median OS for patients treated with chemotherapy (<jats:italic>n<\/jats:italic>\u2009=\u20099) was 447\u2009days, while the median OS for patients undergoing PD\u20101\u2010inhibitor\u2010based therapy (<jats:italic>n<\/jats:italic>\u2009=\u200916) was not reached (<jats:italic>p<\/jats:italic>\u2009=\u20090.105).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SMARCA4\u2010deficient thoracic tumors exhibit distinct characteristics from conventional NSCLCs, and PD\u20101 inhibitors show promise in treating advanced SMARCA4\u2010deficient thoracic tumors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6809","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T07:55:23Z","timestamp":1703145323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinicopathological characteristics and treatment outcomes of advanced <scp>SMARCA4\u2010deficient<\/scp> thoracic tumors"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3951-7938","authenticated-orcid":false,"given":"Anni","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai Lung Cancer Center, Shanghai Chest Hospital Shanghai Jiao Tong University, School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueping","family":"Jin","sequence":"additional","affiliation":[{"name":"Shanghai Lung Cancer Center, Shanghai Chest Hospital Shanghai Jiao Tong University, School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqi","family":"Cao","sequence":"additional","affiliation":[{"name":"Shanghai Lung Cancer Center, Shanghai Chest Hospital Shanghai Jiao Tong University, School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lu","sequence":"additional","affiliation":[{"name":"Shanghai Lung Cancer 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