{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:45:11Z","timestamp":1787795111449,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cisplatin\u2010based chemotherapy is the standard treatment for metastatic ovarian cancer (OC). However, chemoresistance continues to pose significant clinical challenges. Recent research has highlighted the baculoviral inhibitor of the apoptosis protein repeat\u2010containing 5 (BIRC5) as a member of the inhibitor of the apoptosis protein (IAP) family. Notably, BIRC5, which has robust anti\u2010apoptotic capabilities, is overexpressed in numerous cancers. Its dysfunction has been linked to challenges in cancer treatment. Yet, the role of BIRC5 in the chemoresistance of OC remains elusive. In our present study, we observed an upregulation of BIRC5 in cisplatin\u2010resistant cell lines. This upregulation was associated with enhanced chemoresistance, which was diminished when the expression of BIRC5 was silenced. Intriguingly, BIRC5 exhibited a high number of N6\u2010methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) binding sites. The modification of m\n                    <jats:sup>6<\/jats:sup>\n                    A was found to enhance the expression of BIRC5 by recognizing and binding to the 3\u2032\u2010UTR of mRNA. Additionally, the insulin\u2010like growth factor 2 mRNA\u2010binding protein 1 (IGF2BP1) was shown to stabilize BIRC5 mRNA, synergizing with METTL3 and intensifying chemoresistance. Supporting these in\u00a0vitro findings, our in\u00a0vivo experiments revealed that tumors were significantly smaller in size and volume when BIRC5 was silenced. This reduction was notably counteracted by co\u2010silencing BIRC5 and overexpressing IGF2BP1. Our results underscored the pivotal role of BIRC5 in chemoresistance. The regulation of its expression and the stability of its mRNA were influenced by m\n                    <jats:sup>6<\/jats:sup>\n                    A modifications involving both METTL3 and IGF2BP1. These insights presented BIRC5 as a promising potential therapeutic target for addressing cisplatin resistance in OC.\n                  <\/jats:p>","DOI":"10.1002\/cam4.6811","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T06:00:49Z","timestamp":1702965649000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<scp>BIRC5<\/scp>\n                    facilitates cisplatin\u2010chemoresistance in a\n                    <scp>\n                      m\n                      <sup>6<\/sup>\n                      A\n                    <\/scp>\n                    \u2010dependent manner in ovarian cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5592-904X","authenticated-orcid":false,"given":"Yadan","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Gynecology The Second Affiliated Hospital of Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinglian","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Hainan Medical College  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Second Affiliated Hospital of Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Second Affiliated Hospital of Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Second Affiliated Hospital of Hainan Medical University  Haikou 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Hainan Affiliated Hospital of Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchun","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Second Affiliated Hospital of Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15808"},{"issue":"2","key":"e_1_2_10_4_1","first-page":"1","article-title":"Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer","volume":"2","author":"Coleridge SL","year":"2021","journal-title":"Cochrane Database Syst 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