{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:24:15Z","timestamp":1790717055026,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the educational outcomes of siblings of childhood leukemia survivors, explore determinants of school difficulties, and compare the rates of repeating grades between siblings and the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study of childhood leukemia survivors' siblings recruited through the Leuc\u00e9mies de l'Enfant et de l'Adolescent cohort, a French long\u2010term follow\u2010up program, was conducted, and education\u2010related data were obtained via self\u2010report questionnaires. Adjusted logistic regression models were used to identify variables associated with school difficulties and time since diagnosis. Rates of repeating a grade in middle school were compared between siblings and the general population of the same generation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 564 siblings with a mean time from diagnosis of 14.1\u2009\u00b1\u20096.4\u2009years were included, among whom 139 (24.6%) repeated a grade, at an average of 6.4\u2009\u00b1\u20094.5\u2009years after diagnosis. In multivariate analysis, the risk factors for repeating a grade were older siblings (odds ratio [OR] 2.3, <jats:italic>p<\/jats:italic>\u2009=\u20090.006), family financial difficulties (OR 2.8, <jats:italic>p<\/jats:italic>\u2009=\u20090.008), and history of repetition in survivors (OR, 2.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Sibling hematopoietic stem cell donors were at greater risk of repeating a grade long\u2010term after diagnosis (<jats:italic>p<\/jats:italic>\u2009=\u20090.018). Overall, siblings did not have a higher risk of educational delays at the end of middle school than the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the results are reassuring, socioeconomic and cancer\u2010related factors may have an impact on siblings' schooling long after diagnosis. Paying attention to siblings contributes to identifying the most vulnerable families, allowing more attention and appropriate resources to avoid long\u2010term repercussions. Additionally, supportive and targeted interventions can be developed to improve the organization of education and the health care system.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6821","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T06:13:32Z","timestamp":1704953612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Educational outcomes in siblings of childhood leukemia survivors: Factors associated with school difficulties and comparison with general population"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-342X","authenticated-orcid":false,"given":"Cindy","family":"Faust","sequence":"first","affiliation":[{"name":"UR 3279, CERESS \u2013 Health Service Research and Quality of Life Center Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Auquier","sequence":"additional","affiliation":[{"name":"UR 3279, CERESS \u2013 Health Service Research and Quality of Life Center Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Gandemer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology University Hospital of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology University Hospital of Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Dominique","family":"Tabone","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology A. Trousseau Hospital, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Ansoborlo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology University Hospital of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Baruchel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology, Robert Debr\u00e9 Hospital GHU AP\u2010HP Nord Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacinthe","family":"Bonneau","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology University Hospital of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Hugues","family":"Dalle","sequence":"additional","affiliation":[{"name":"Department of Pediatric 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