{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T11:23:32Z","timestamp":1772623412383,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to examine the associations between the use of statins concurrent with androgen deprivation therapy (ADT) and the risks of mortality in Asian patients diagnosed with prostate cancer (PCa).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult patients (\u226518\u2009years old) diagnosed with PCa who were receiving any form of ADT and were being treated at public hospitals in Hong Kong from December 1999 to March 2021 were retrospectively identified, with follow\u2010up conducted until September 2021. Patients who had received medical castration for &lt;180\u2009days without subsequent bilateral orchidectomy, those who had used statins concurrently with ADT for &lt;180\u2009days, and those with missing baseline total cholesterol levels were excluded. Statin users were defined as individuals who had used statins for \u2265180\u2009days concurrent with ADT, while non\u2010users were those who had not used any statins. PCa\u2010related mortality was the primary outcome, while all\u2010cause mortality served as the secondary outcome. Inverse probability treatment weighting was employed to balance the covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4920 patients were included, consisting of 2578 statin users and 2342 non\u2010users (mean age 76.1\u2009\u00b1\u20098.2\u2009years). Over a mean follow\u2010up period of 4.2\u2009\u00b1\u20093.3\u2009years, it was observed that statin users had significantly lower risks of both PCa\u2010related mortality (weighted hazard ratio [wHR] 0.56 [95% confidence interval (CI) 0.48, 0.65], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and all\u2010cause mortality (wHR 0.57 [95% CI 0.51, 0.63], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), regardless of the type of ADT used. Notably, these associations were more pronounced among patients with less advanced PCa, as indicated by the absence of androgen receptor antagonist or chemotherapy usage (<jats:italic>p<\/jats:italic> value for interaction &lt;0.001 for both outcomes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion(s)<\/jats:title><jats:p>The use of statins concurrent with ADT was associated with reduced mortality risks among Asian patients with PCa. These findings suggest the need for additional research to explore the potential role of statins in the treatment of PCa patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6826","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T06:28:40Z","timestamp":1703312920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Statin use and mortality risk in Asian patients with prostate cancer receiving androgen deprivation therapy: A population\u2010based cohort study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0740-1598","authenticated-orcid":false,"given":"Yan Hiu Athena","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"},{"name":"Cardio\u2010Oncology Research Unit, Cardiovascular Analytics Group PowerHealth Limited  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Limited  Hong Kong China"},{"name":"Quest Genomics Limited  London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6119-0889","authenticated-orcid":false,"given":"Edward Christopher","family":"Dee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenrick","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology University College London Hospitals NHS Foundation Trust  London United 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