{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:46:34Z","timestamp":1767015994504,"version":"3.41.2"},"reference-count":72,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002794"],"award-info":[{"award-number":["82002794"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The causal association between osteoarthritis (OA) and bladder cancer remains unclear. This Mendelian randomization (MR) study was carried out to assess the potential causal effects of any OA, knee OA and hip OA, and bladder cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Genome\u2010wide association study (GWAS) summary data for OA and bladder cancer were obtained in GWAS CATALOG, UK Biobank, and FinnGen Consortium. Inverse\u2010variance weighted (IVW) approach was primarily conducted to evaluate the causal relationships between OA and bladder cancer, and MR\u2010Egger intercept and Cochran's <jats:italic>Q<\/jats:italic> test were mainly used to estimate heterogeneity and pleiotropy. MR\u2010PRESSO was used to test the presence of horizontal outliers. Leave\u2010one\u2010out analysis was utilized to ensure the reliability of the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A higher genetic predisposition to any OA has a causal association with bladder cancer risk, while neither knee OA nor hip OA is causally linked to bladder cancer. MR\u2010Egger intercept analysis exhibited that any OA and knee OA had no pleiotropic effect on the risk of bladder cancer, and Cochran's <jats:italic>Q<\/jats:italic> test showed that any OA, knee OA and hip OA had no heterogeneity on bladder cancer risk. Neither MR PRESSO analysis nor leave\u2010one\u2010out analysis revealed any outlier SNPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This MR study exhibited a positive cause\u2010and\u2010effect relationship between any type of OA and bladder cancer risk, but not between site\u2010specific OA, knee OA and hip OA, and bladder cancer. Attention should be paid to the screening and prevention of bladder cancer in OA patients at any site.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6829","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T17:26:13Z","timestamp":1702661173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The causal relationship between osteoarthritis and bladder cancer: A Mendelian randomization study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-7493","authenticated-orcid":false,"given":"Xi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Medical Oncology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengjin","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Qingdao Medical College Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixuan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiluo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijun","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30417-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.10.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22171"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.11.001"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2019.10.007"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1025063"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.892742"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2023.03.026"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa719"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2022.2085883"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-023-01538-3"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010320"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104154"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2022.06.006"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.793023"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.12.001"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-022-08941-1"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-2867(97)80009-6"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002108"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.07.039"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-02984-4"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/551S33a"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.09.001"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2022.10.003"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa166"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab733"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-015-0011-z"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.118216"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280215597579"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00954-4"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04103-z"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05473-8"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.992599"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.5808\/GI.2016.14.4.173"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21965"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv080"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990531)81:5<719::AID-IJC8>3.0.CO;2-D"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2010.05.011"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/109350703321530855"},{"issue":"3","key":"e_1_2_11_41_1","first-page":"199","article-title":"Risk factors for early osteoarthritis in tenosynovial giant cell tumour","volume":"64","author":"Machado V","year":"2020","journal-title":"Rev Esp Cir Ortop Traumatol"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199609000-00002"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32711"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094483"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.11.012"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.01.019"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21565"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2081465"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2019.08.004"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199819010-00004"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.06.013"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14476"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.4178\/epih.e2022050"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.996440"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.768529"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa597"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.2337\/db20-0084"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23334"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.106023"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03225-y"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.02.150"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2021.1903488"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq437"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070008"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27590"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-13-0164"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2019.11.27"},{"issue":"12","key":"e_1_2_11_68_1","first-page":"Cr604","article-title":"The relationship between NSAID use and osteoarthritis (OA) severity in patients with hip and knee OA: results of a case control study of NSAID use comparing those requiring hip and knee replacements to those in whom surgery was not recommended","volume":"14","author":"Pope JE","year":"2008","journal-title":"Med Sci Monit"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n2321"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-021-00726-8"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2015.08.001"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000081"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2013.863969"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T10:30:41Z","timestamp":1714127441000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,15]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/cam4.6829"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6829","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"type":"print","value":"2045-7634"},{"type":"electronic","value":"2045-7634"}],"subject":[],"published":{"date-parts":[[2023,12,15]]},"assertion":[{"value":"2023-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6829"}}