{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:49:51Z","timestamp":1783118991730,"version":"3.54.6"},"reference-count":79,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA21765"],"award-info":[{"award-number":["P30 CA21765"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 GM92666"],"award-info":[{"award-number":["P30 GM92666"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD093754"],"award-info":[{"award-number":["R01 HD093754"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 HD082307"],"award-info":[{"award-number":["R21 HD082307"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 CA225590"],"award-info":[{"award-number":["T32 CA225590"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The primary aim of this study was to assess the feasibility of a developmentally tailored neurocognitive assessment in survivors of childhood acute leukemia with Down syndrome (DS\u2010leukemia). A secondary aim was to compare outcomes in the DS\u2010leukemia group to a historical comparison group of individuals with DS and no history of childhood cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Survivors of DS\u2010leukemia (<jats:italic>n<\/jats:italic>\u2009=\u200943; 56% male, mean [SD] age at diagnosis\u2009=\u20094.3 [4.5] years; age at evaluation\u2009=\u200915 [7.9] years) completed a neurocognitive assessment battery that included direct measures of attention, executive function, and processing speed, and proxy ratings of attention problems and executive dysfunction. Direct assessment outcomes were compared to a historical comparison cohort of individuals with DS and no history of childhood cancer (DS\u2010control; <jats:italic>n<\/jats:italic>\u2009=\u2009117; 56% male, mean [SD] age at evaluation\u2009=\u200912.7 [3.4] years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rates of valid task completion ranged from 54% to 95%, suggesting feasibility for most direct assessment measures. Compared to the DS\u2010control group, the DS\u2010leukemia group had significantly lower completion rates on measures of executive function (<jats:italic>p<\/jats:italic>\u2009=\u20090.008) and processing speed (<jats:italic>p<\/jats:italic>\u2009=\u20090.018) compared to the DS\u2010control group. There were no other significant group differences in completion rates. Compared to the DS\u2010control group, the DS\u2010leukemia group had significantly more accurate performance on two measures of executive function (<jats:italic>p<\/jats:italic>\u2009=\u20090.032; <jats:italic>p<\/jats:italic>\u2009=\u20090.005). Compared to the DS\u2010control group, the DS\u2010leukemia group had significantly more problems with executive function as identified on proxy ratings (6.5% vs. 32.6%, <jats:italic>p<\/jats:italic>\u2009=\u2009&lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children with Down syndrome (DS) are at increased risk for developing acute leukemia compared to the general population but are systematically excluded from neurocognitive outcome studies among leukemia survivors. This study demonstrated the feasibility of evaluating neurocognitive late effects in leukemia survivors with DS using novel measures appropriate for populations with intellectual developmental disorder.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6842","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T09:25:15Z","timestamp":1705656315000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neurocognitive and psychosocial outcomes in survivors of childhood leukemia with Down syndrome"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4769-9114","authenticated-orcid":false,"given":"Kellen","family":"Gandy","sequence":"first","affiliation":[{"name":"Department of Psychology and Biobehavioral Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Department of Social Sciences University of Houston Downtown  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lacey","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Psychology and Biobehavioral Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Krull","sequence":"additional","affiliation":[{"name":"Department of Psychology and Biobehavioral Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna J.","family":"Esbensen","sequence":"additional","affiliation":[{"name":"Division of Developmental and Behavioral Pediatrics Cincinnati Children's Hospital Medical Center &amp; University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9885-3527","authenticated-orcid":false,"given":"Jeffrey","family":"Rubnitz","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2698-5816","authenticated-orcid":false,"given":"Lisa M.","family":"Jacola","sequence":"additional","affiliation":[{"name":"Department of Psychology and Biobehavioral Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"NooneAM HowladerN KrapchoM et\u00a0al.SEER cancer statistics review 1975\u20132015.2018seer.cancer.gov\/csr\/1975_2015. Bethesda MD."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.2315"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02322"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3470"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30283-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaa102"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02444"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25749"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20735"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0143-7"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2012.01619.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34252"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1624-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(00)00435-6"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05264-2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-11-163501"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-509463"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27256"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12739"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14085"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.5060"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27249"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.3205"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20397"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21820"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs344"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-4-42"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21992"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24464"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.4149"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.5408"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.82.5.353"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.117066"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200202000-00010"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.01055.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/15.7.603"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.9055"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(02)00260-5"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24666"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.5.810"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.7587"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25362"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25981"},{"key":"e_1_2_9_45_1","unstructured":"National Scientific Council on the Developing Child.The Science of Early Childhood Development:Closing the Gap Between What We Know and What We Do. Retrieved from.www.developingchild.harvard.edu.2007."},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.161.10.933"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31439"},{"key":"e_1_2_9_48_1","first-page":"371","article-title":"Child behavior checklist","volume":"7","author":"Achenbach TM","year":"1991","journal-title":"Burlington (Vt)"},{"key":"e_1_2_9_49_1","volume-title":"BRIEF: Behavior Rating Inventory of Executive Function","author":"Gioia GA","year":"2015"},{"key":"e_1_2_9_50_1","unstructured":"BruininksRH WoodcockRW WeathermanRF HillBK.Scales of independent behavior\u2010revised. SIB\u2010R. Riverside Publishing Itasca.1996."},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000001"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-016-9167-4"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1348\/014466507X230967"},{"key":"e_1_2_9_54_1","volume-title":"Neuropsychological Evaluation of the Child New York","author":"Baron IS","year":"2004"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2010.01262.x"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/02643290802274064"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.21.2.229.928"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15326942dn3101_6"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjdp.12003"},{"issue":"6","key":"e_1_2_9_60_1","first-page":"616","article-title":"Detection of Alzheimer's disease in individuals with Down syndrome","volume":"99","author":"Nelson L","year":"1995","journal-title":"Am J Ment Retard"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1006\/brcg.1999.1117"},{"key":"e_1_2_9_62_1","volume-title":"Kaufman Brief Intelligence Test","author":"Kaufman AS","year":"2004"},{"key":"e_1_2_9_63_1","volume-title":"Released 2021. IBM SPSS Statistics for Windows, Version 28.0","author":"IBM Corp","year":"2021"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20065202"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2022.104358"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1352\/1944-7558-124.3.220"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/19315864.2014.920941"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1352\/1944-7558-119.4.303"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2015.00264"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1352\/1944-7558-116.4.290"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1352\/1944-7558-122.3.247"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkab069"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25730"},{"key":"e_1_2_9_74_1","unstructured":"Children's Oncology Group.Long Term Follow Up Guidelines for children adolescent and young adult cancers version 5.0.2018www.survivorshipguidelines.org\/pdf\/2018\/LTFU_Guidelines_V5.pdf"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.76.3.367"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.6672"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3222"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23354"},{"key":"e_1_2_9_79_1","first-page":"440","article-title":"Exercise training for neural recovery in a restricted sample of pediatric brain tumor survivors: a controlled clinical trial with crossover of training versus no training","volume":"19","author":"Riggs L","year":"2017","journal-title":"Neuro Oncol"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25692"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T06:09:11Z","timestamp":1712642951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,19]]},"references-count":79,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/cam4.6842"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6842","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,19]]},"assertion":[{"value":"2023-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6842"}}