{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:46:31Z","timestamp":1792079191626,"version":"4.4.0"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Older cancer survivors often value quality of life (QOL) over survival. Life\u2010space mobility (LSM), defined as the individual's spatial geographic mobility range, is an important QOL indicator in older adults with chronic illnesses; however, this relationship is unexplored in older cancer survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined the longitudinal associations and causal relationships between LSM and QOL in 153 older cancer survivors (\u226565\u2009years) from the University of Alabama at Birmingham (UAB) Study of Aging. LSM was assessed using the UAB Life\u2010Space Assessment\u2010Composite score (LSA\u2010C), and QOL was assessed by the SF\u201012 Mental Component Score (MCS12) and Physical Component Score (PCS12) at 0 (study entry), 6, 18, 36, 54, and 72\u2009months. We examined the causal relationship between LSM and QOL using a cross\u2010lagged panel model (CLPM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort (<jats:italic>n<\/jats:italic>\u2009=\u2009153) was 76\u2009years old on average and predominantly White (58%), female (58%), and married (55%). Longitudinal analyses found LSM decreased over time (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and this decrease was associated with decreased QOL (PCS12, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001, MCS12, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). In the CLPM causal analysis, lower LSM resulted in worse PCS12 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but not worse MSC12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Restricted LSM resulted in worse physical QOL over 72\u2009months in a sample of 153 older cancer survivors. Developing and evaluating interventions to preserve greater LSM could be a promising approach to improving QOL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6850","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T06:38:23Z","timestamp":1703313503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Restricted life\u2010space mobility impacts physical but not mental quality of life in older cancer survivors"],"prefix":"10.1002","volume":"13","author":[{"given":"Richard A.","family":"Taylor","sequence":"first","affiliation":[{"name":"School of Nursing University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Bakitas","sequence":"additional","affiliation":[{"name":"School of Nursing University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Wells","sequence":"additional","affiliation":[{"name":"School of Nursing University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6764-0254","authenticated-orcid":false,"given":"J. 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