{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:33:51Z","timestamp":1786977231876,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["Number 112\u2010S0215"],"award-info":[{"award-number":["Number 112\u2010S0215"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diffuse large B\u2010cell lymphoma (DLBCL) of the head\u2010and\u2010neck area primarily involves the Waldeyer ring (WR) and sinonasal area (SN). However, the differential clinical outcomes between patients with WR\u2010DLBCL and those with SN\u2010DLBCL in the rituximab era remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To avoid confounding factors contributed by advanced DLBCL with WR and SN involvement, we assessed the clinical outcomes of patients with stage I\/II WR\u2010DLBCL and SN\u2010DLBCL and compared them with those having corresponding stages of DLBCL in the lymph nodes but without other extranodal involvement (LN\u2010DLBCL) in the same period. We compared the patients' clinical characteristics, treatment modalities, event\u2010free survival (EFS), and overall survival (OS) among the three subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We analyzed 67, 15, and 106 patients with WR\u2010DLBCL, SN\u2010DLBCL, and LN\u2010DLBCL, respectively, between January 2000 and December 2019. All patients received front\u2010line rituximab\u2010based regimens, and\u2009&gt;\u200980% received rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone\u2010based regimens. More patients with SN\u2010DLBCL had revised International Prognostic Index (R\u2010IPI) score 3 (27%) when compared with those with WR\u2010DLBCL (7%) and those with LN\u2010DLBCL (10%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.181). Patients with WR\u2010DLBCL, LN\u2010DLBCL, and SN\u2010DLBCL had 5\u2010year EFS and OS rates of 80.7%, 59.5%, and 41.9% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021) and 83.7%, 70.8%, and 55.8% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032), respectively. Compared to patients with LN\u2010DLBCL, those with WR\u2010DLBCL also had a significantly favorable 5\u2010year EFS rate (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021) and 5\u2010year OS rate (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023). Three of the 15 patients with SN\u2010DLBCL experienced lymphoma recurrence in the brain after front\u2010line treatment. In multivariate analyses, R\u2010IPI scores of 1\u20132 and 3 served as significantly poor prognostic factors for patients with poor EFS and OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared to patients with LN\u2010DLBCL, patients with WR\u2010DLBCL receiving front\u2010line rituximab\u2010based treatments had favorable clinical outcomes; however, patients with SN\u2010DLBCL had worse clinical outcomes. Further studies on molecular prognostic factors and treatment strategies for SN\u2010DLBCL are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6851","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T01:11:30Z","timestamp":1703639490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Improved outcomes of localized diffuse large B\u2010cell lymphoma at the Waldeyer ring in comparison to the sinonasal area in the rituximab era"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6840-2976","authenticated-orcid":false,"given":"Wei\u2010Li","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Oncology National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei City Taiwan"},{"name":"Cancer Research Center National Taiwan University College of Medicine  Taipei City 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Taiwan University Hospital and National Taiwan University College of Medicine  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang\u2010Ju","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5042-0503","authenticated-orcid":false,"given":"Chung\u2010Wu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei City Taiwan"},{"name":"Department of Pathology and Laboratory Medicine Koo Foundation Sun Yat\u2010Sen Cancer Center  Taipei City 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