{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:59:18Z","timestamp":1783382358741,"version":"3.54.6"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The introduction of novel hormonal therapies represented by enzalutamide (ENZ) and abiraterone acetate (ABI) has reached a great progress in the treatment of metastatic castration\u2010resistant prostate cancer (mCRPC). The majority of mCRPC patients are elderly suffering from chronic co\u2010morbidities requiring use of various concomitant medications. In the present study, we focused on impact of concomitant antihypertensive medication on the outcomes of mCRPC patients treated with ENZ or ABI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 300 patients were included and their clinical data were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Angiotensin\u2010converting enzyme inhibitors (ACEIs) represented the only concomitant medication significantly associated with survival. The median radiographic progression\u2010free survival (rPFS) and overall survival (OS) for patients using ACEIs were 15.5 and 32.3\u2009months compared to 10.7 and 24.0\u2009months for those not using ACEIs (<jats:italic>p<\/jats:italic>\u2009=\u20090.0053 and <jats:italic>p<\/jats:italic>\u2009=\u20090.0238, respectively). Cox multivariable analysis revealed the use of ACEIs a significant predictive factor for both rPFS (HR\u2009=\u20090.704, <jats:italic>p<\/jats:italic>\u2009=\u20090.0364) and OS (HR\u2009=\u20090.592, <jats:italic>p<\/jats:italic>\u2009=\u20090.0185).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings of this study suggest an association between the concomitant use of ACEIs and longer survival of mCRPC patients receiving ENZ or ABI therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6853","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T08:24:16Z","timestamp":1704183856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Concomitant antihypertensive medication and outcome of patients with metastatic castration\u2010resistant prostate cancer receiving enzalutamide or abiraterone acetate"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4096-7385","authenticated-orcid":false,"given":"Ond\u0159ej","family":"Fiala","sequence":"first","affiliation":[{"name":"Department of Oncology and Radiotherapeutics, Faculty of Medicine and University Hospital in Pilsen Charles University  Pilsen Czech Republic"},{"name":"Biomedical Center, Faculty of Medicine in Pilsen Charles University  Pilsen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Ho\u0161ek","sequence":"additional","affiliation":[{"name":"Biomedical Center, Faculty of Medicine in Pilsen Charles University  Pilsen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Korunkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Oncology and Radiotherapeutics, Faculty of Medicine and University Hospital in Pilsen Charles University  Pilsen Czech 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