{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T21:26:27Z","timestamp":1755033987275,"version":"3.41.2"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Myocardial work (MW) is a new echocardiographic tool with a high sensitivity to detect early and subtle alterations of myocardial function. We aimed to evaluate the late effects of anthracyclines by assessing the global and segmental MW and intraventricular mechanical dispersion from speckle tracking echocardiography in childhood lymphoma survivors (CLS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010one young adults including CLS and age\u2010matched healthy controls were enrolled. All underwent echocardiography including an evaluation of left ventricular (LV) morphology and regional function. We assessed LV longitudinal (differentiating sub\u2010endocardial and sub\u2010epicardial layers), circumferential strains and twist, global and regional MW index (MWI). LV mechanical dispersion was assessed from the time dispersion of LV longitudinal strain, from myocardial wasted work (MWW) and myocardial work efficiency (MWE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The longitudinal strains both at the level of the sub\u2010endocardium and sub\u2010epicardium were reduced in CLS compared to controls. The global MWI was also decreased (1668\u2009\u00b1\u2009266 vs 1870\u2009\u00b1\u2009264%.mmHg in CLS patients and controls, respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), especially on the apical segments. An increase of LV intraventricular mechanical dispersion was observed in CLS. MWW and MWE remained unchanged compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results strongly support that cardiac remodeling is observed in CLS, characterized by a decrease in MW and an increase in LV mechanical dispersion. The apex is specifically altered, but its clinical significance remains uncertain. MW as a complement to strain seems interesting in cancer survivors to detect myocardial dysfunction at early stage and adapt their follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6857","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T07:14:19Z","timestamp":1704957259000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anthracycline\u2010induced cardiotoxicity on regional myocardial work and left ventricular mechanical dispersion in adolescents and young adults in post\u2010lymphoma remission"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6945-5943","authenticated-orcid":false,"given":"Mohamed","family":"Jaber","sequence":"first","affiliation":[{"name":"CHU Clermont\u2010Ferrand, P\u00e9diatrie G\u00e9n\u00e9rale  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Armand","sequence":"additional","affiliation":[{"name":"CHU de Clermont\u2010Ferrand, Service H\u00e9matologie Oncologie P\u00e9diatrique  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Rochette","sequence":"additional","affiliation":[{"name":"CHU Clermont\u2010Ferrand, P\u00e9diatrie G\u00e9n\u00e9rale  Clermont\u2010Ferrand France"},{"name":"Universit\u00e9 Clermont Auvergne, INSERM CIC 1405, CRECHE Unit  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Severine","family":"Monzy","sequence":"additional","affiliation":[{"name":"Cardiologue lib\u00e9ral, P\u00f4le Sant\u00e9 R\u00e9publique  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Greze","sequence":"additional","affiliation":[{"name":"CHU de Clermont\u2010Ferrand, Service H\u00e9matologie Oncologie P\u00e9diatrique  Clermont\u2010Ferrand France"},{"name":"Universit\u00e9 Clermont Auvergne, INSERM CIC 1405, CRECHE Unit  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Kanold","sequence":"additional","affiliation":[{"name":"CHU de Clermont\u2010Ferrand, Service H\u00e9matologie Oncologie P\u00e9diatrique  Clermont\u2010Ferrand France"},{"name":"Universit\u00e9 Clermont Auvergne, INSERM CIC 1405, CRECHE Unit  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Merlin","sequence":"additional","affiliation":[{"name":"CHU Clermont\u2010Ferrand, P\u00e9diatrie G\u00e9n\u00e9rale  Clermont\u2010Ferrand France"},{"name":"CHU de Clermont\u2010Ferrand, Service H\u00e9matologie Oncologie P\u00e9diatrique  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Paysal","sequence":"additional","affiliation":[{"name":"CHU de Clermont\u2010Ferrand, Service H\u00e9matologie Oncologie P\u00e9diatrique  Clermont\u2010Ferrand France"},{"name":"CHU Clermont\u2010Ferrand, N\u00e9onatologie et R\u00e9animation P\u00e9diatrique  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Nottin","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Adaptations to Exercise  Avignon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30186-9"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2020.101733"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115000906"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4606"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950240604"},{"issue":"6","key":"e_1_2_12_7_1","first-page":"39","article-title":"Cardiotoxicity in cancer patients treated with chemotherapy: a systematic review","volume":"16","author":"Lima MAC","year":"2022","journal-title":"Int J Health Sci (Qassim)"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002661"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/sux019"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1957"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.07.012"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.073"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12079"},{"key":"e_1_2_12_14_1","first-page":"360","volume-title":"Comprehensive Textbook of Echocardiography","author":"Padmanabhan S","year":"2014"},{"key":"e_1_2_12_15_1","first-page":"1","article-title":"Two\u2010dimensional speckle tracking echocardiography detects subclinical left ventricular systolic dysfunction among adult survivors of childhood, adolescent, and young adult cancer","volume":"2016","author":"Yu AF","year":"2016","journal-title":"BioMed Res Int"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-021-01028-4"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.02.012"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2011.01429.x"},{"issue":"12","key":"e_1_2_12_19_1","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.119.008869","article-title":"Echocardiographic assessment of cardiac function in pediatric survivors of anthracycline\u2010treated childhood cancer. Circ","volume":"12","author":"Slieker MG","year":"2019","journal-title":"Cardiovasc Imag"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.798774"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.11.017"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hjc.2022.07.007"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194521"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2022.2093131"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs016"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00191.2013"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.02.014"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2010.06.007"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-48"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13759"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-023-07812-5"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002852"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.662882"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.082"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13743"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14222"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.019"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.02.006"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes143"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-021-10119-4"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23326"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.06.067"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23388"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-022-04447-2"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.04.007"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2016.12.015"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.04.018"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47407"},{"key":"e_1_2_12_50_1","first-page":"1176","volume-title":"Comprehensive Textbook of Echocardiography","author":"Buckberg G","year":"2014"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2009.07.004"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2020.08.006"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.194118"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.03.006"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T06:07:19Z","timestamp":1712642839000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,10]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/cam4.6857"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6857","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"type":"print","value":"2045-7634"},{"type":"electronic","value":"2045-7634"}],"subject":[],"published":{"date-parts":[[2024,1,10]]},"assertion":[{"value":"2023-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6857"}}