{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T21:03:45Z","timestamp":1774645425173,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1411400"],"award-info":[{"award-number":["22ZR1411400"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To improve the early detection rate of multiple myeloma (MM), the M\u2010protein screening system has been performed in the hospital population at Zhongshan Hospital Fudan University since 2014, with electrophoretic\u2010based monoclonal immunoglobulin (M\u2010protein) screening integrated into the blood biochemistry panel. This study updated 7\u2010year follow\u2010up findings of MM patients diagnosed by screening\u2010driven and symptom\u2010driven approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<jats:bold>s<\/jats:bold><\/jats:title><jats:p>The retrospective study compared the characteristics and outcomes of patients diagnosed through two patterns by reviewing the plasma cell disease database from January 2014 to October 2021. The screening\u2010driven group included patients diagnosed through the screening system during workups of unrelated medical conditions or routine checkups. In contrast, patients who visited or were referred to the hematological department due to myeloma\u2010related end\u2010organ damage were categorized into the symptom\u2010driven group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 3,110,218 serum protein electrophoresis (SPEP) tests performed during 7\u2009years, with 1.95% (60,609) patients yielding positive SPEP results. Of 911 confirmed MM cases (excluding concurrent amyloidosis), 366 were assigned to the screening\u2010driven group, while 545 were to the symptom\u2010driven group. Compared to the symptom\u2010driven group, the screening group had more IgG subtypes, earlier International Stage System stages, fewer disease\u2010related symptoms, lower ECOG scores, less extramedullary disease, a lower percentage of bone marrow plasma cells, and a lower level of lactate dehydrogenase. Frontline response results of two groups were similar. Patients detected through screening had a significantly improved median progression\u2010free survival (PFS) than the symptom\u2010driven group (62.2 vs. 24.9\u2009months, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, HR: 2.12, 95% CIs: 1.69\u20132.65), with median follow\u2010ups of 32.6 and 27.4\u2009months. Furthermore, the median overall survival (OS) was significantly longer in patients of the screening group (not reached vs. 62.3\u2009months, <jats:italic>p\u2009&lt;<\/jats:italic>\u20090.001, HR: 2.49, 95% CIs: 1.81\u20133.41). After being adjusted for well\u2010acknowledged myeloma prognostic factors, the screening\u2010driven diagnostic pattern remained an independent prognostic factor indicating improved PFS and OS in MM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Routine M\u2010protein screening for MM in the hospital population results in an earlier diagnosis and better patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6859","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T14:10:00Z","timestamp":1703254200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Update on the outcome of M\u2010protein screening program of multiple myeloma in China: A 7\u2010year cohort study"],"prefix":"10.1002","volume":"13","author":[{"given":"Wenjing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology Zhongshan Hospital Fudan 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