{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:02:22Z","timestamp":1787605342801,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Myelodysplastic syndromes (MDS) are myeloid neoplasms characterized by ineffective hematopoiesis due to stem cell abnormalities. Monosomy 7q aberrations are a common cytogenetic abnormality in MDS. Specifically, an unbalanced translocation der(1;7)(q10;p10) [der(1;7)] has been identified in MDS patients, which is a monosomy 7q aberration variant like \u22127\/del(7q). However, knowledge of der(1;7)'s features remains limited. Existing studies have compared the clinical and genetic characteristics of der(1;7) to those of \u22127\/del(7q) but yielded inconsistent findings. Accordingly, we conducted meta\u2010analyses comparing der(1;7) to \u22127\/del(7q).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Publications were searched from the following databases up to January 10, 2023: Pubmed, Web of Science, Embase, Cochrane, and ClinicalTrials.gov. Eligible studies were assessed for risks of bias. Relevant data were extracted from included studies and analyzed using random\u2010effects models. Publication bias was evaluated and sensitivity analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The comparative meta\u2010analyses included 405 MDS patients with der(1;7) from nine studies. The analysis revealed that der(1;7) was associated with a greater male preponderance (86.1% vs. 68.3%, Odds Ratios (ORs) 2.007, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) than \u22127\/del(7q), lower platelets counts compared to del(7q), higher hemoglobin levels than \u22127, lower absolute neutrophil counts, and higher percentage of patients with non\u2010excess blasts (66.9% vs. 41.3%, ORs 2.374, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) in comparison with \u22127\/del(7q). The der(1;7) existed more as a sole karyotype aberration (55.6% vs. 37.0%, ORs 2.902, <jats:italic>p<\/jats:italic>\u2009=\u20090.02), co\u2010occurred more often with +8 (22.7% vs. 4.2%, ORs 5.714, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) whereas less \u22125\/del(5q) (1.5% vs. 41.3%, ORs 0.040, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and complex karyotype (7.3% vs. 54.8%, OR 0.085, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The der(1;7) was associated with higher frequencies of <jats:italic>RUNX1<\/jats:italic> (40.8% vs. 12.3%, ORs 4.764, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), <jats:italic>ETNK1<\/jats:italic> (28.1% vs. 2.5%, ORs 42.106, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and <jats:italic>EZH2<\/jats:italic> (24.8% vs. 6.9%, ORs 3.767, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) mutations, but less <jats:italic>TP53<\/jats:italic> mutation (2.4% vs. 45.3%, ORs 0.043, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Moreover, der(1;7) patients had longer time to progression (Hazard Ratios (HRs) 0.331, <jats:italic>p<\/jats:italic>\u2009=\u20090.02), better overall survival (OS) than \u22127 patients (HRs 0.557, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), but similar OS with del(7q) patients (HRs 0.837, <jats:italic>p<\/jats:italic>\u2009=\u20090.37).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings revealed distinct clinical, cytogenetic, and molecular characteristics distinguishing der(1;7) from \u22127\/del(7q), indicating der(1;7) defines a unique subtype within MDS with monosomy 7q. These findings support classifying der(1;7) as a separate MDS entity in future.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6890","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T07:54:15Z","timestamp":1704182055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The der(1;7)(q10;p10) defining a distinct profile from \u22127\/del(7q) in myelodysplastic syndromes: A\u00a0systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"13","author":[{"given":"Wei","family":"Lang","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingwan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-4160","authenticated-orcid":false,"given":"Hongyan","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhejiang University  Hangzhou China"},{"name":"Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy Zhejiang University  Hangzhou China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological disorders  Hangzhou China"},{"name":"Zhejiang University Cancer Center  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1904794"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-092304"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-12-822,262"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-082404"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-420,489"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404619"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.228"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0031"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012781"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22760"},{"key":"e_1_2_10_12_1","unstructured":"Bruy\u00e8reH.der(1;7)(q10;p10). 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