{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:52:27Z","timestamp":1770745947970,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection on postoperative recovery of non\u2010small cell lung cancer (NSCLC) is need to be understood, thereby informing the optimal timing of surgical decision\u2010making during the COVID\u201019 pandemic for NSCLC patients. This study reports the postoperative outcomes of surgical NSCLC patients with preoperative SARS\u2010CoV\u20102 infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This single\u2010center retrospective cohort study included 241 NSCLC patients who underwent lobectomy or sub\u2010lobectomy between December 1, 2022 and February 14, 2023. Surgical outcomes of patients with preoperative SARS\u2010CoV\u20102 infection (stratified by the time from diagnosis of SARS\u2010CoV\u20102 infection to surgery) were compared with those without preoperative SARS\u2010CoV\u20102 infection. The primary outcomes were total postoperative complications and postoperative pulmonary complications (PPCs), the secondary outcomes included operation time, total postoperative drainage and time, length of hospital stay (LOS), 30\u2010day and 90\u2010day postoperative symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study included 153 (63.5%) patients with preoperative SARS\u2010CoV\u20102 infection and 88 (36.5%) patients without previous SARS\u2010CoV\u20102 infection. In patients with a preoperative SARS\u2010CoV\u20102 diagnosis, the incidence of total postoperative complications (OR, 3.00; 95% CI, 1.12\u20138.01; <jats:italic>p<\/jats:italic>\u2009=\u20090.028) and PPCs (OR, 4.20; 95% CI, 1.11\u201315.91; <jats:italic>p<\/jats:italic>\u2009=\u20090.035) both increased in patients infected having surgery within 2\u2009weeks compared with non\u2010infection before surgery. However, patients who underwent lung resection more than 2\u2009weeks after SARS\u2010CoV\u20102 diagnosis had a similar risk of postoperative complications and surgical outcomes with those non\u2010infection before surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study to provide evidence regarding the optimum timing of lung resection surgery and assessing early outcomes after surgery in NSCLC patients with SARS\u2010CoV\u20102 infection. Our study documents that the SARS\u2010CoV\u20102 infection did not complicate surgical procedures for lung cancer, and suggest that lung surgery should be postponed at least 2\u2009weeks after SARS\u2010CoV\u20102 infection for NSCLC patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6891","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T05:59:27Z","timestamp":1704261567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimum timing of lung resection surgery following SARS\u2010CoV\u20102 infection for non\u2010small cell lung cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Yanbo","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Thoracic Surgery, Shangjin Branch of Western China Hospital Sichuan University  Chengdu 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